Page
%P
25 Result(s)
within
Teruo Okano
Materials Science
-
Article
Measurement of the dynamic behavior of thin poly(N-isopropylacrylamide) hydrogels and their phase transition temperatures measured using reflectometric interference spectroscopy
Temperature-responsive cell culture surfaces prepared by modifying tissue-culture polystyrene with nanoscale poly(N-isopropylacrylamide) (PIPAAm) hydrogels are widely used as intelligent surfaces for the fabricat...
-
Article
Control of Cell Adhesion and Detachment on Temperature-Responsive Block Copolymer Langmuir Films
This study used Langmuir-Schaefer (LS) method to produce thermo-responsive poly(N-isopropylacrylamide) (PIPAAm) modified surface. Block copolymer composed of polystyrene (PSt) and PIPAAm was synthesized by RAFT p...
-
Article
Biofunctional Thermo-Responsive Polymeric Surface with Micropatterns for Label Free Cell Separation
Thready stripe-patterned thermo-responsive surfaces were prepared and their surface properties were characterized. Prepared 3 μm wide stripe-patterned surfaces were evaluated by observing the adhesions and det...
-
Book
-
Chapter
Stimuli-Responsive Hydrogels and Their Application to Functional Materials
Many kinds of stimuli-responsive polymer gels that respond to the change in their surroundings such as solvent composition, temperature, pH, and supply of electric field have been developed. They are of intere...
-
Article
Cell-Sheet Engineering Using Intelligent Surfaces
The possibility of recreating various tissues and organs for the purpose of regenerative medicine has received much interest. However, the field of tissue engineering has been restricted by the limitations of ...
-
Chapter and Conference Paper
Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer
A poly(N-isopropylacrylamide)-coated glass was prepared and its interfacial electrokinetic properties were studied with a special emphasis on the phase transition behavior of the hydrogel. The electro-osmotic ...
-
Chapter and Conference Paper
Pharmaceutical Aspects of Block Copolymer Micelles
We studied the stability of micelles of poly(ethylene oxide-block-ß benzyl L aspartate) (PEO-PBLA) containing doxorubicin (DOX), an anti-cancer drug. DOX entrapped in PEO-PBLA micelles had greater chemical stabil...
-
Chapter and Conference Paper
Application of Hema-St Block Copolymer Coated Small Caliber Vascular Graft for Veins
We were already reported that the amphiphilic block copolymer composed from 2-hydroxyethylmathacryrate and styrene(HSB) which formed micro-domain structure show excellent nonthombogenicity. In this study, we a...
-
Chapter and Conference Paper
Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin
Micelle forming polymeric drug(MFPD) containing chemically bound and physically incorporated adriamycin(ADR) was designed. Three MFPD samples containing various contents of physically incorporated ADR were pre...
-
Chapter and Conference Paper
Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells
Poly(N-sopropylacrylamide) (PIPAAm)-grafted surfaces show hydrophilic/hydrophobic surface property alteration upon temperature changes. Utilizing this property changes, we can cultivate cells on its surface at 37...
-
Chapter and Conference Paper
The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads
We investigate the possible applicability of alginate gel beads for controlled release system of water-soluble macromolecular drugs, using Fluorescein Isothiocyanate Dextran (FITC-dex) as the model compound. L...
-
Chapter and Conference Paper
Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups
The ternary copolymers composed of m-acrylamidophenylboronic acid, N,N-dimethylaminopropylmethacrylamide and N-isopropylacrylamide were synthesized. Bovine aortic endothelial cells (BAECs) on the copolymer substr...
-
Chapter and Conference Paper
Intelligent Materials
Poly(N-isopropylacrylamide) (PIPAAm) is well-known to change its structure in response to temperature in aqueous solutions [1,2]. Polymer chains of IPAAm hydrate to form expanded structures in water at lower solu...
-
Chapter and Conference Paper
Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH
An insulin delivery system comprising phenylboronic acid (PBA) hydrogel was investigated for efficacy at physiological pH by an addition of amino moiety. Release of gluconated insulin from hydrogel beads havin...
-
Chapter and Conference Paper
Molecular Architecture of Temperature-Responsive Bioconjugates
Chemical modification of biomolecules with synthetic and natural polymers has developed new applications of proteins in the fields of medicine, bio-engineering and bioreactor. We have been investigating polyme...
-
Chapter and Conference Paper
Thermo-Responsive Polymer Surfaces for Cell Culture: Analysis of the Surfaces and Control of the Cell Attachment / Detachment
Poly(N-isopropylacrylamide)(PIPAAm) has been applied to thermal on-off switching polymers for drug release[l]. We have reported that, when PIPAAm is grafted on the surface of a cell culture dish, the cells cul...
-
Chapter and Conference Paper
Molecular Design of Artificial Lectin; Recognition and Killer Cell Induction of Lymphocytes by a Novel Water Soluble Polymer Having Phenylboronic Acid Moiety
To design of synthetic polymer with mitogenic propertiy, a novel water-soluble polymer was synthesized by radical copolymerization of 3-acrylamidophenylboronic acid with dimethylacrylamide (poly(DMAA-co-PBA))....
-
Chapter and Conference Paper
Temperature Responsive Swelling-Deswelling Kinetics of Poly(N-Isopropylacrylamide) Grafted Hydrogels
A new approach is proposed to speeding up a deswelling response to temperature in a polymer hydrogel by tailoring the gel architecture at the molecular level. This novel structural design allows rapid conforma...
-
Chapter and Conference Paper
Development of Polymeric Micelles for Drug Delivery of Indomethacin
To estimate a feasibility of novel containers for drugs, poly(ethylene oxide)-poly(ß-benzyl L-aspartate) (PEO-PBLA) micelles were prepared by dialysis into water from different solvents (e.g., DMF, acetonitril...
