Skip to main content

13 Result(s)

within Teruo Okano Remove this filter Biomedicine Remove this filter Pharmacy Remove this filter

and

  1. No Access

    Article

    Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting

    Purpose. Polymeric micelles were designed for targeting of a water-insoluble anticancer agent, camptothecin (CPT). Chemical structures of inner core segment were optimized to achieve high incorporation efficienc...

    Praneet Opanasopit, Masayuki Yokoyama, Masato Watanabe… in Pharmaceutical Research (2004)

  2. No Access

    Book

    Polymer Drugs in the Clinical Stage

    Advantages and Prospects

    Hiroshi Maeda, Alexander Kabanov… in Advances in Experimental Medicine and Biology (2003)

  3. No Access

    Chapter

    Challenges in Polymer Therapeutics

    Alexander V. Kabanov, Teruo Okano in Polymer Drugs in the Clinical Stage (2003)

  4. No Access

    Article

    Soluble Self-Assembled Block Copolymers for Drug Delivery

    Glen S. Kwon, Teruo Okano in Pharmaceutical Research (1999)

  5. No Access

    Article

    Permeation of PEO-PBLA-FITC Polymeric Micelles in Aortic Endothelial Cells

    Purpose. To determine aortic endothelial cells permeation ability and mechanisms of the aqueous block copolymeric micelles, poly(ethylene oxide)-poly ((β-benzyl L-aspartate) (PEO-PBLA) chemically conjugated with...

    Jiahorng Liaw, Takao Aoyagi, Kazunori Kataoka, Yasuhisa Sakurai… in Pharmaceutical Research (1999)

  6. No Access

    Article

    Visualization of PEO-PBLA-Pyrene Polymeric Micelles by Atomic Force Microscopy

    Purpose. To directly visualize and evaluate the aqueous block copolymeric micelles, poly(ethylene oxide)-poly(β-benzyl L-aspartate) (PEO-PBLA) chemically conjugated with pyrene fluorescence molecule, by nanotech...

    Jiahorng Liaw, Takao Aoyagi, Kazunori Kataoka, Yasuhisa Sakurai… in Pharmaceutical Research (1998)

  7. No Access

    Article

    Glucose-Responsive Gel from Phenylborate Polymer and Poly (Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of Borate with Amino Group in the Gel

    Purpose. To design glucose-responsive gels based on the complexation between polymers having phenylboronic acid groups and poly (vinyl alcohol). Specifically, high-glucose sensitivity at physiological pH was ach...

    Issei Hisamitsu, Kazunori Kataoka, Teruo Okano, Yasuhisa Sakurai in Pharmaceutical Research (1997)

  8. No Access

    Article

    Physical Entrapment of Adriamycin in AB Block Copolymer Micelles

    The entrapment of Adriamycin (ADR) in micelles composed of AB block copolymers (poly(ethylene oxide-co-β-benzyl L-aspartate) (PEO-PBLA)) was investigated. The loading process involved transfer of ADR and PEO-P...

    Glen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano… in Pharmaceutical Research (1995)

  9. No Access

    Article

    Biodistribution of Micelle-Forming Polymer–Drug Conjugates

    Polymeric micelles have potential utility as drug carriers. To this end, polymeric micelles based on AB block copolymers of polyethylene oxide (PEG) and poly(aspartic acid) [p(Asp)] with covalently bound Adria...

    Glen S. Kwon, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai… in Pharmaceutical Research (1993)

  10. No Access

    Article

    Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography

    The micelle-forming behavior of a drug–block copolymer conjugate adriamycm-conjugated poly(ethylene glycol)–poly(aspartic acid) block copolymer; PEG-P[Asp(ADR)] was analyzed by gel permeation chromatography (G...

    Masayuki Yokoyama, Takumichi Sugiyama, Teruo Okano… in Pharmaceutical Research (1993)

  11. No Access

    Article

    Hydrogels: Swelling, Drug Loading, and Release

    Hydrogels have been used by many investigators in controlled-release drug delivery systems because of their good tissue compatibility and easy manipulation of swelling level and, thereby, solute permeability. ...

    Sung Wan Kim, You Han Bae, Teruo Okano in Pharmaceutical Research (1992)

  12. No Access

    Article

    “On–Off“ Thermocontrol of Solute Transport. II. Solute Release from Thermosensitive Hydrogels

    Poly(N-isopropylacrylamide) (NIPAAm)/polytetramethylene ether glycol (PTMEG) interpenetrating polymer networks (IPNs) were synthesized and their feasibility as thermosensitive hydrogels for drug release was inves...

    You Han Bae, Teruo Okano, Sung Wan Kirn in Pharmaceutical Research (1991)

  13. No Access

    Article

    “On–Off” Thermocontrol of Solute Transport. I. Temperature Dependence of Swelling of N-Isopropylacrylamide Networks Modified with Hydrophobic Components in Water

    The swelling in water, as a function of temperature, of two series of N-isopropylacrylamide (NIPA Am) polymer networks was studied. In the first series, n-butylmethacrylate (BMA) was copolymerized with NIPA Am, a...

    You Han Bae, Teruo Okano, Sung Wan Kim in Pharmaceutical Research (1991)