21 Result(s)

Article

Diagnostic value of peroral cholangioscopy in addition to computed tomography for indeterminate biliary strictures

Peroral cholangioscopy (POCS) has been used to overcome the difficulty in diagnosing indeterminate biliary stricture or tumor spread. However, the value of adding POCS to computed tomography (CT) remains uncle...

Yukiko Shima, Harutoshi Sugiyama, Sadahisa Ogasawara, Motoyasu Kan… in Surgical Endoscopy (2022)

Article

Development of Rapid Simulation Code for NBI Heating Analysis in LHD

We develop a rapid simulation code for neutral beam injection (NBI) heating analysis, FIT3D-RC, to evaluate the power deposition in NBI-heated plasmas of the Large Helical Device (LHD). This code evaluates the...

Yuya Morishita, Sadayoshi Murakami, Masayuki Yokoyama… in Journal of Fusion Energy (2021)

Article

Stability evaluation of Gd chelates for macromolecular MRI contrast agents

We try to establish designs for the macromolecular agents possessing high Gd³⁺-chelating stability, because free Gd³⁺ ion released from Gd chelates is known as a risk factor to cause toxic side effects and a safe...

Masayuki Yokoyama, Kouichi Shiraishi in Magnetic Resonance Materials in Physics, B… (2020)

Article

Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan

Background Conversion from sorafenib to regorafenib is primarily an evidence-based treatment strategy in patients with advanced hepatocellular carcinoma (HCC). This study aimed to assess the safety and efficacy o...

Sadahisa Ogasawara, Yoshihiko Ooka, Norio Itokawa… in Investigational New Drugs (2020)

Article

Characteristics of patients with sorafenib-treated advanced hepatocellular carcinoma eligible for second-line treatment

Background Regorafenib has been investigated for its efficacy and safety as a second-line treatment in patients with advanced hepatocellular carcinoma (HCC). We assessed the characteristics of pa...

Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka… in Investigational New Drugs (2018)

Chapter

Clinical Diagnostic Imaging

In this section, we describe clinical imaging technologies with a focus of targeting methodology and photochemical imaging modality. First, we discuss the targeting methodology for imaging diagnosis by compari...

Masayuki Yokoyama, Kouichi Shiraishi in Photochemistry for Biomedical Applications (2018)

Article

Tumor Environment Changed by Combretastatin Derivative (Cderiv) Pretreatment That Leads to Effective Tumor Targeting, MRI Studies, and Antitumor Activity of Polymeric Micelle Carrier Systems

To evaluate effect of a vascular disrupting agent, a combretastatin derivative (Cderiv), on tumor targeting for polymeric micelle carrier systems, containing either a diagnostic MRI contrast agent or a therape...

Kouichi Shiraishi, Yoshiko Harada, Kumi Kawano, Yoshie Maitani… in Pharmaceutical Research (2012)

Article

Accelerated Blood Clearance Was Not Induced for a Gadolinium-Containing PEG-poly(L-lysine)-Based Polymeric Micelle in Mice

Accelerated blood clearance (ABC) is induced by repeated injections of PEGylated liposomes. In this study, the ABC was investigated for a gadolinium-containing PEG-poly(L-lysine)-based polymeric micelle (Gd-mi...

Huili Ma, Kouichi Shiraishi, Takuya Minowa, Kumi Kawano… in Pharmaceutical Research (2010)

Article

Anti-tumor Effect of All-Trans Retinoic Acid Loaded Polymeric Micelles in Solid Tumor Bearing Mice

All-trans retinoic acid (ATRA) polymeric micelles were developed for parenteral administration. The distribution characteristics and antitumor activities of ATRA polymeric micelles were evaluated after intravenou...

Narin Chansri, Shigeru Kawakami, Masayuki Yokoyama… in Pharmaceutical Research (2008)

Article

Drug targeting with nano-sized carrier systems

This paper discusses the present status of, and future perspectives on, drug targeting through the bloodstream by describing the drug targeting concept, its methodologies, types of drug carriers, and recent cl...

Masayuki Yokoyama in Journal of Artificial Organs (2005)

Chapter

Controlled Release of DNA Using Thermoresponsive Polymers

Masayuki Yokoyama in Non-viral Gene Therapy (2005)

Article

Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting

Purpose. Polymeric micelles were designed for targeting of a water-insoluble anticancer agent, camptothecin (CPT). Chemical structures of inner core segment were optimized to achieve high incorporation efficienc...

Praneet Opanasopit, Masayuki Yokoyama, Masato Watanabe… in Pharmaceutical Research (2004)

Chapter and Conference Paper

Pharmaceutical Aspects of Block Copolymer Micelles

We studied the stability of micelles of poly(ethylene oxide-block-ß benzyl L aspartate) (PEO-PBLA) containing doxorubicin (DOX), an anti-cancer drug. DOX entrapped in PEO-PBLA micelles had greater chemical stabil...

Glen S. Kwon, Mayumi Naito… in Advanced Biomaterials in Biomedical Engine… (1996)

Chapter and Conference Paper

Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin

Micelle forming polymeric drug(MFPD) containing chemically bound and physically incorporated adriamycin(ADR) was designed. Three MFPD samples containing various contents of physically incorporated ADR were pre...

Takashi Seto, Shigeto Fukushima… in Advanced Biomaterials in Biomedical Engine… (1996)

Article

Physical Entrapment of Adriamycin in AB Block Copolymer Micelles

The entrapment of Adriamycin (ADR) in micelles composed of AB block copolymers (poly(ethylene oxide-co-β-benzyl L-aspartate) (PEO-PBLA)) was investigated. The loading process involved transfer of ADR and PEO-P...

Glen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano… in Pharmaceutical Research (1995)

Article

Heterobifunctional poly(ethylene oxide)

Well-defined poly(ethylene oxide)s with a primary amino group at one end and a hydroxyl group at the other terminus were synthesized with new sila-protected amino functionality initiator, potassium N-[2-(2,2,5...

Yong Joo Kim, Yukio Nagasaki, Kazunori Kataoka, Masao Kato… in Polymer Bulletin (1994)

Article

Biodistribution of Micelle-Forming Polymer–Drug Conjugates

Polymeric micelles have potential utility as drug carriers. To this end, polymeric micelles based on AB block copolymers of polyethylene oxide (PEG) and poly(aspartic acid) [p(Asp)] with covalently bound Adria...

Glen S. Kwon, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai… in Pharmaceutical Research (1993)