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Article
Open AccessProgression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease
The clinical meaningfulness of the effects of recently approved disease-modifying treatments (DMT) in Alzheimer’s disease is under debate. Available evidence is limited to short-term effects on clinical rating...
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Article
Open AccessA cell abundance analysis based on efficient PAM clustering for a better understanding of the dynamics of endometrial remodelling
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for investigating cell abundance changes during tissue regeneration and remodeling processes. Differential cell abundance supports the initial clusteri...
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Article
Open AccessScellpam: an R package/C++ library to perform parallel partitioning around medoids on scRNAseq data sets
Partitioning around medoids (PAM) is one of the most widely used and successful clustering method in many fields. One of its key advantages is that it only requires a distance or a dissimilarity between the i...
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Chapter
Select Rare Disease Drug Approvals: Lessons Learned
Until the passage of the US Orphan Drug Act of 1983, only a small number of rare diseases had approved therapies. Since then, there has been a marked increase in rare disease research funding and development e...
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Chapter and Conference Paper
IOWA Operators and Its Application to Image Retrieval
This paper presents a relevance feedback procedure based on logistic regression analysis. Since, the dimension of the feature vector associated to each image is typically larger than the number of evaluated im...
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Chapter
Cross-Efficiency in Fuzzy Data Envelopment Analysis (FDEA): Some Proposals
Different techniques have been proposed in the literature to rank decision making units (DMUs) in the context of Fuzzy Data Envelopment Analysis. In our opinion, those that result from using a ranking method t...
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Chapter
Mathematics and Soft Computing in Music
Mathematics is the fundamental tool for dealing with the physical processes that explain music but it is also in the very essence of this art. Musical notes, the first elements which music works with, are defi...
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Article
Open AccessA patient survey of the impact of fibromyalgia and the journey to diagnosis
Fibromyalgia is a painful, debilitating illness with a prevalence of 0.5-5.0% that affects women more than men. It has been shown that the diagnosis of fibromyalgia is associated with improved patient satisfac...
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Chapter and Conference Paper
Obtaining the Compatibility between Musicians Using Soft Computing
Modeling the musical notes as fuzzy sets provides a flexible framework which better explains musicians’ daily practices. Taking into account one of the characteristics of the sound: the pitch (the frequency of...
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Chapter and Conference Paper
Compatibility of the Different Tuning Systems in an Orchestra
Focusing on the daily practice of musicians, we give flexibility to the mathematical treatment of musical notes, tuning systems and the relations between them. This allows us to connect the theory and the prac...
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Chapter and Conference Paper
Measuring Dissimilarity Between Curves by Means of Their Granulometric Size Distributions
The choice of a dissimilarity measure between curves is a key point for clustering functional data. In this paper we propose to obtain the granulometric distribution functions of the original curves and then c...
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Chapter
Fuzzy Logic for Medical Engineering: An Application to Vessel Segmentation
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Article
Zeolite as source of saline nutrients in solid state fermentation of sugarcane straw bytrichoderma citrinoviride
Trichoderma citrinoviride, isolated from soil of Havana, Cuba, utilised sugarcane straw with high yields for cellulolytic enzyme in solid state fermentation. The solid bed containing natural zeolite supplies all...
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Article
Two Fuzzy Approaches for Solving Multiobjective Decision Problems
Zimmermann (1978) proposed a fuzzy method for solving multiple objectivedecision problems whose main difficulty is in specifying the membershipfunctions of the objectives. We have considered two different appr...
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Chapter
Optimization under Uncertainty and Linear Semi-Infinite Programming: A Survey
This paper deals with the relationship between semi-infinite linear programming and decision making under uncertainty in imprecise environments. Actually, we have reviewed several set-inclusive constrained mod...
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Chapter and Conference Paper
Fuzzy Mathematical Programming for Portfolio Management
The classical portfolio selection problem was formulated by Markowitz in the 1950s as a quadratic programming problem in which the risk variance is minimized. Since then, many other models have been considered...
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Article
A multi-local optimization algorithm
The development of efficient algorithms that provide all the local minima of a function is crucial to solve certain subproblems in many optimization methods. A “multi-local” optimization procedure using inexac...
