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  1. No Access

    Article

    Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

    This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT (fragile histidine triad) inactivation in lung, breast and bladder cancers; (b) examin...

    Dimitrios Iliopoulos, Gulnur Guler, Shuang-Yin Han, Danika Johnston… in Oncogene (2005)

  2. No Access

    Article

    CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors

    To determine if: (1) 5′ CpG island methylation is related to Fhit inactivation; (2) there are tumor or carcinogen-specific methylation patterns, we examined 35 CpG sites in the promoter, exon and intron 1 of the ...

    Shuang-Yin Han, Dimitrios Iliopoulos, Teresa Druck, Gulnur Guler… in Oncogene (2004)

  3. No Access

    Protocol

    Analyzing the FHIT Gene by RT-PCR, Western Blotting, and Immunohistochemistry

    FHIT (fragile histidine triad) is a tumor-suppressor gene located at chromosome band 3p14.2. The genomic locus, which is greater than 1 Mb, contains 10 small exons that make up the 1.1-kb FHIT cDNA. The coding re...

    Raffaele Baffa, Coleen M. Calviello, Teresa Druck, Leonard G. Gomella in Renal Cancer (2001)