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  1. Article

    Open Access

    Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

    Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cr...

    Teresa Druck, Douglas G. Cheung, Dongju Park, Francesco Trapasso… in Cell Death & Disease (2019)

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  2. No Access

    Article

    Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

    This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT (fragile histidine triad) inactivation in lung, breast and bladder cancers; (b) examin...

    Dimitrios Iliopoulos, Gulnur Guler, Shuang-Yin Han, Danika Johnston… in Oncogene (2005)

  3. No Access

    Article

    CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors

    To determine if: (1) 5′ CpG island methylation is related to Fhit inactivation; (2) there are tumor or carcinogen-specific methylation patterns, we examined 35 CpG sites in the promoter, exon and intron 1 of the ...

    Shuang-Yin Han, Dimitrios Iliopoulos, Teresa Druck, Gulnur Guler… in Oncogene (2004)

  4. No Access

    Protocol

    Analyzing the FHIT Gene by RT-PCR, Western Blotting, and Immunohistochemistry

    FHIT (fragile histidine triad) is a tumor-suppressor gene located at chromosome band 3p14.2. The genomic locus, which is greater than 1 Mb, contains 10 small exons that make up the 1.1-kb FHIT cDNA. The coding re...

    Raffaele Baffa, Coleen M. Calviello, Teresa Druck, Leonard G. Gomella in Renal Cancer (2001)

  5. No Access

    Article

    Chromosomal localization of four human zinc finger cDNAs

    cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc finger (ZNF) consensus sequences. Unique cDNA clones were mapped in the human genome...

    Kay Huebner, Teresa Druck, Sal LaForgia, Jerzy Lasota, Carlo M. Croce… in Human Genetics (1993)