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Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro

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  1. Article

    Open Access

    Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

    As the only cells capable of efficiently resorbing bone, osteoclasts are central mediators of both normal bone remodeling and pathologies associates with excessive bone resorption. However, despite the clear e...

    P. Edward Purdue, Tania N. Crotti, Zhenxin Shen, Jennifer Swantek… in Scientific Reports (2014)

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  2. Article

    Open Access

    The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

    The immunoreceptor tyrosine-based activation motif (ITAM) pathway provides osteoclast co-stimulatory signals and regulates proliferation, survival and differentiation of effector immune cells. In the osteoclas...

    Tania N Crotti, Anak ASSK Dharmapatni, Ekram Alias… in Arthritis Research & Therapy (2012)

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  3. Article

    Open Access

    TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis

    TNF-like weak inducer of apoptosis (TWEAK) has been proposed as a mediator of inflammation and bone erosion in rheumatoid arthritis (RA). This study aimed to investigate TWEAK and TWEAK receptor (Fn14) express...

    Anak ASSK Dharmapatni, Malcolm D Smith, Tania N Crotti… in Arthritis Research & Therapy (2011)

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  4. Article

    Open Access

    The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis

    Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particles released from the implant components induce a granu...

    Zhenxin Shen, Tania N Crotti, Kevin P McHugh… in Arthritis Research & Therapy (2006)

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