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Article
Open AccesssurviveR: a flexible shiny application for patient survival analysis
Kaplan–Meier (KM) survival analyses based on complex patient categorization due to the burgeoning volumes of genomic, molecular and phenotypic data, are an increasingly important aspect of the biomedical resea...
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Article
Open AccessclassifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes
Transcriptionally informed predictions are increasingly important for sub-ty** cancer patients, understanding underlying biology and to inform novel treatment strategies. For instance, colorectal cancers (CR...
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Article
Open AccessMolecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant
Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemo...
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Article
Open AccessThe SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 ...
