-
Chapter
Induction of Antibodies to Pseudorabies Virus by Immunization with Anti-Idiotypic Antibodies
In 1974, Niels Jerne (10) proposed that an anti-idiotypic antibody (anti-anti-X) might sometimes express an “internal image” of X; i.e., that the combining region of the anti-idiotypic (anti-Id) antibody could...
-
Chapter
Molecular Biology of Pseudorabies Virus
Pseudorabies virus (PRV) causes a natural infection in swine similar to that of herpes simplex virus (HSV) in man, and B virus in monkeys. Sabin (1934) was the first to recognize that these viruses are natural...
-
Chapter
Summary
Discussion at part 1 of session I touched on many aspects of herpes simplex virus (HSV) infection including the effect of prior immunization on HSV challenge, the role of immunity in the establishment and mainten...
-
Chapter
Latency of Pseudorabies Virus
The restriction patterns of genomes of twelve different field isolates of PrV were analyzed. All were found to differ. In most cases, the basis of the differences in restriction patterns was found to lie in th...
-
Chapter
Organization and Replication of Pseudorabies Virus DNA
The genome of Pr virus, swine herpesvirus, consists of a linear, double-stranded DNA molecule, molecular weight approximately 90 × 106 (5, 21). Pr viral DNA has a relatively high G+C content (73 moles %) (2) and ...
-
Chapter
Replication of Herpesvirus DNA
The genomes of the herpesviruses are large complex DNA molecules with several interesting and perhaps unique properties. In the past few years the structure of these genomes has generated considerable interest, a...
-
Article
Studies on the Biogenesis of Herpesvirus Envelope
THE nucleocapsid of the herpesvirus is surrounded by an envelope which the virion acquires by budding from the nuclear membrane of the infected cell1–4. The viral envelope, however, contains glycoproteins which d...
-
Article
Polyoma Virus-induced Release of inhibition of Cellular DNA Synthesis caused by Iododeoxyuridine
THE halogenated pyrimidine nucleosides, 5-iodo-2′-deoxyuridine (IUdR) and 5-bromo-2′-deoxyuridine (BUdR), are incorporated instead of thymidine into the DNA of mammalian cells for one division cycle. The synth...
