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Article
Effect of Methyl-substitution of the Quinoline Ring of Cinchona Alkaloids on the Performance as a Modifier for the Enantioselective Hydrogenation of (E)-2,3-di(4-methoxyphenyl)propenoic Acid Over Pd/C: Kinetic Analysis
The asymmetric hydrogenation of (E)-2,3-di(4-methoxyphenyl)propenoic acid was conducted over Pd/C chirally modified with cinchona alkaloids methyl-substituted at 2′-position of the quinoline ring. It is revealed ...
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Article
Open AccessIn the beginning when the Japanese Environmental Mutagen Society was established
Upon the commemoration of the 10th anniversary of the journal, “Genes and Environment”, the history of sciences on environmental mutagens in Japan was reviewed.
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Article
EXAFS Characterization of Pd Catalysts for Enantioselective Hydrogenation of α-Phenylcinnamic Acid: Pretreatment Effects and Thiol Adsorption
The effects of the pretreatment and Pd-distribution on the enantioselective hydrogenation of α-phenylcinnamic acid over cinchonidine-modified Pd/C and Pd/Al2O3 were studied by use of EXAFS techniques combined wit...
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Article
Enantioselective hydrogenation of α-phenylcinnamic acids over cinchonidine-modified Pd/C commercial catalysts
Enantioselective hydrogenation of α-phenylcinnamic acid (PCA) and p,p′-dimethoxyphenylcinnamic acid (DMPCA) was studied over a variety of commercial 5 % Pd/C catalysts to reveal catalyst properties suitable for o...
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Article
Induction period for the enantioselective hydrogenation of α,β-unsaturated acids over a cinchonidine-modified palladium catalyst
The enantioselective hydrogenation of α-phenylcinnamic acid (PCA) was performed using a cinchonidine (CD)-modified Pd/C catalyst, and the conversion and enantiomeric excess (ee) of the product were monitored d...
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Protocol
Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot
The original 32P-postlabeling method developed by Randerath and his colleagues has been modified to detect a single type of adduct as a single spot in thin-layer chromatography (TLC), because some types of adduct...
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Article
Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone
The hydrogenation of 5-alkylidene-2,4-thiazolidiones was studied using Pd/C to establish an alternative process for pioglitazone synthesis. The reportedly sluggish reactivity was due to the high reaction tempe...
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Article
Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae
Cabbage butterfly, Pieris rapae, contains a unique DNA ADP-ribosylating protein, pierisin-1, which transfers ADP-ribose moiety of NAD to guanine bases of DNA. Pierisin-like proteins are only distributed in subtri...
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Article
Enantioselective Hydrogenation of Olefins using Commercially Available Pd/C. Chiral Heterogeneous Catalyst Applicable for High-Throughput Screening
Cinchonidine-modified Pd/C applicable for the high-throughput-guided study was developed. Commercial Pd/C catalysts were employed for the enantioselective hydrogenation of phenylcinnamic acid after the pretrea...
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Article
Open AccessGenotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems
Recently, manufactured nano/microparticles such as fullerenes (C60), carbon black (CB) and ceramic fiber are being widely used because of their desirable properties in industrial, medical and cosmetic fields. How...
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Article
Conditioning of Palladium-on-carbon (Pd/C) for Uniform Cinchonidine Modification to Perform Highly Enantioselective Hydrogenation
Cinchonidine (CD)-modified palladium catalyst gave the high product ee when a commercial wet Pd/C was used after the co-evaporation pretreatment. The improvement in the ee was attributed to removal of water fr...
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Article
Enantioselective Hydrogenation in Water Over Chiral Modified Heterogeneous Catalyst Admixed With Organic Solvent
Hydrogenation of α,β-unsaturated acid over cinchonidine-modified Pd/C results in poor enantioselectivity in water, but the selectivity becomes much higher when Pd/C is admixed with a small amount of a hydrophobic...
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Article
Enantioselective Hydrogenation of (E)-α-phenylcinnamic Acid over Cinchonidine-modified Pd Catalysts Supported on TiO2 and CeO2
The effects of the catalyst support, reaction temperature, and concentration of the modifier were examined to optimize supported Pd-catalysts and reaction conditions for the achievement of higher enantiomeric ...
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Article
Open AccessErratum To: Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
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Article
Open AccessLoss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. Howeve...
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Article
Highly enantioselective hydrogenation of α-Alkyl-β-arylpropenoic acids over cinchonidine-modified palladium catalyst
Enantioselective hydrogenation of (E)- α-alkyl-β-arylpropenoic acids was studied over the cinchonidine-modified Pd/C under the conditions optimized for (E)-α,β-diarylpropenoic acids. Enantiomeric excess (ee) of t...
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Chapter
Role of Poly-ADP-Ribosylation in Cancer Development
Elucidation of the relationship between poly-ADP-ribosylation and carcinogenesis has markedly progressed by the recent development of knockout or transgenic mice models of poly(ADP-ribose) polymerase (Parp)-1,...
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Article
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent
Accumulated evidence suggests that Parp-1 is involved in DNA repair processes, including base excision repair, single-strand and double-strand break repairs. To understand the precise role of Parp-1 in genomic...
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Protocol
Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot
The original 32P-postlabeling method developed by Randerath and his colleagues has been modified to detect a single type of adduct as a single spot in thin-layer chromatography (TLC), because some types of adduct...
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Article
Identification of 27 5′ CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
Aberrantly methylated DNA fragments were searched for in human pancreatic cancers, using the genome scanning technique: methylation-sensitive-representational difference analysis (MS-RDA). MS-RDA isolated 111 ...
