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Article
Methylated SEPT9 assay-based liquid biopsy as a biomarker in molecular targeted agent-treated hepatocellular carcinoma
The development of molecular targeted agents (MTAs) has changed the treatment strategy for hepatocellular carcinoma (HCC). However, currently, there are no established predictive biomarkers for the treatment e...
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Article
A combination of liver stiffness and international normalized ratio is an ideal prognostic predictor of portosystemic shunt occlusion in patients with portal hypertension
We previously reported liver stiffness (LS) as a prognostic predictor of portosystemic shunt (PSS) occlusion. This study aims to reinvestigate the predictive factors of the model for end-stage liver disease-so...
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Article
Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin
Defensins are cationic antimicrobial peptides with a broad spectrum. Recently human β-defensin 2 (hBD-2) has been isolated from psoriatic skin; however, its exact localization and fate have not been fully und...
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Article
Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts
Human neutrophil peptide-1 (HNP-1), a defensin with antimicrobial properties, is also thought to promote wound healing. To elucidate the mechanism by which wound healing is facilitated by this factor, we inves...
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Article
Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer
Prolidase deficiency is an autosomal recessive inherited disease characterized clinically by frequent infections, mental retardation, and various skin lesions. Fundamental treatments for these manifestations h...
