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Article
Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice
Menaquinone-4 (MK-4) is an isoform of vitamin K2 that has been shown to exert various biological actions besides its functions in blood coagulation and bone metabolism. Here we examined the effect of MK-4 on a mo...
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Article
Optimal conditions for the use of polyrotaxane as a cross-linker in preparing elastomers with high toughnesses
The effects of the cyclic molecules within polyrotaxanes moving over axial molecules serving as cross-linking points in a polymeric network preclude observation of the cyclic effects in polymer networks compos...
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Article
Open AccessMirabegron displays anticancer effects by globally browning adipose tissues
Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact of global adipose metabo...
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Article
Preparation and characterization of two-dimensional sheet-shaped poly(methyl methacrylate) synthesized via γ-ray polymerization in nanoclay template
Two-dimensional sheet-shaped poly(methyl methacrylate) (2d-PMMA) with crosslinking only in the two-dimensional direction was synthesized via planar polymerization of MMA monomer in montmorillonite (MMT) nanola...
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Cerebellar Biochemistry/Pharmacology
Cerebellar Purkinje cells (PCs) are localized in the cerebellar cortex and are characterized by highly developed dendrites, which receive different inputs from the parallel fibers of cerebellar granule cells, ...
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Article
Open AccessCOVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Patients with COVID-19 frequently manifest adipose atrophy, weight loss and cachexia, which significantly contribute to poor quality of life and mortality1,2. Browning of white adipose tissue and activation of br...
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Article
Open AccessBrown-fat-mediated tumour suppression by cold-altered global metabolism
Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues1–6. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metast...
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Article
Open AccessA Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice
We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hem...
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Article
Open AccessSimple linear ionic polysiloxane showing unexpected nanostructure and mechanical properties
Polysiloxanes are ubiquitous materials in industry and daily life derived from silicates, an abundant resource. They exhibit various properties, which depend on the main-chain network structure. Linear (1D bac...
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Article
Open AccessIncorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials
Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4 ∙ 5H2O) is a precursor of hydroxyapatite found in human bones and teeth, and is among the inorganic substances critical for hard tissue formation and regeneration in t...
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Article
Open AccessPhoto-triggered large mass transport driven only by a photoresponsive surface skin layer
Since the discovery 25 years ago, many investigations have reported light-induced macroscopic mass migration of azobenzene-containing polymer films. Various mechanisms have been proposed to account for these m...
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Article
Open AccessTherapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors
FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating FGF-2+ tumors are unavailable. Here we show that FGF-2 modulates tumor vessels by...
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Article
Open AccessCETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
The use of taxanes has for decades been crucial for treatment of several cancers. A major limitation of these therapies is inherent or acquired drug resistance. A key to improved outcome of taxane-based therap...
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Article
Open AccessPhotoinitiated Marangoni flow morphing in a liquid crystalline polymer film directed by super-inkjet printing patterns
Slight contaminations existing in a material lead to substantial defects in applied paint. Herein, we propose a strategy to convert this nuisance to a technologically useful process by using an azobenzene-cont...
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Article
Open AccessSpontaneous synthesis of a homogeneous thermoresponsive polymer network composed of polymers with a narrow molecular weight distribution
We have developed a method to obtain a polymer gel consisting of a relatively homogeneous network structure composed of polymers with a narrow molecular weight simply by mixing the necessary compounds. In this...
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Article
Open AccessDual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling
Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is...
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Article
Open AccessA miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
Understanding the molecular mechanisms regulating beige adipocyte formation may lead to the development of new therapies to combat obesity. Here, we report a miRNA-based autocrine regulatory pathway that contr...
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Article
Open AccessStructural color coating films composed of an amorphous array of colloidal particles via electrophoretic deposition
It is desirable to fabricate colorful coatings that have nonfading properties and are environmentally friendly. In this study, a novel approach for creating structural color coatings from monodisperse silica p...
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New Strategies for Light-Induced Alignment and Switching in Liquid Crystalline Polymers
The photoalignment processes in liquid crystal films are based on the occurrence of angular selective photoreactions by linearly polarized light or oblique incidence of light. Alignment of nematic liquid cryst...
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Article
Regulatory Mechanisms of Vitamin D3 on Production of Nitric Oxide and Pro-inflammatory Cytokines in Microglial BV-2 Cells
Inhibition of pro-inflammatory functions of microglia has been considered a promising strategy to prevent pathogenic events in the central nervous system under neurodegenerative conditions. Here we examined po...
