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Article
Open AccessBone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model
Non-alcoholic fatty liver disease (NAFLD) is frequently accompanied by iron overload. However, because of the complex hepcidin-regulating molecules, the molecular mechanism underlying iron overload remains unk...
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Article
Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase
Iron overload remains a concern in myelodysplastic syndrome (MDS) patients. Iron chelation therapy (ICT) thus plays an integral role in the management of these patients. Moreover, ICT has been shown to prolong...
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Article
Effectiveness of pazopanib for postoperative recurrence of granulocyte colony-stimulating factor-producing primary hepatic angiosarcoma
A 38-year-old Japanese woman was referred to our hospital with complaints of fever, general fatigue, and upper abdominal discomfort. Computed tomography revealed a massive tumor in the right lobe of the liver,...
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Chapter
Waist Circumference Correlates and Hepatic Fat Accumulation
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and is a major public health problem worldwide. It has been suggested that simple fatty liver, the most common type of NAFLD,...
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Article
Body iron metabolism and pathophysiology of iron overload
Iron is an essential metal for the body, while excess iron accumulation causes organ dysfunction through the production of reactive oxygen species. There is a sophisticated balance of body iron metabolism of s...
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Article
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and telangiectasia1,2,3. The etiology of this disorder is un...
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Article
Enlarging splenic vein aneurysm associated with increasing portal hypertension
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Article
Usefulness of recombinant Em18-ELISA to evaluate efficacy of treatment in patients with alveolar echinococcosis
Alveolar echinococcosis (AE) is a rare parasitic disease caused by Echinococcus multicularis and most commonly involves the liver. Early diagnosis is essential to improve the prognosis of patients with AE of the ...
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Article
Innate antimicrobial peptide protects the skin from invasive bacterial infection
In mammals, several gene families encode peptides with antibacterial activity, such as the β-defensins and cathelicidins1,2,3. These peptides are expressed on epithelial surfaces and in neutrophils, and have been...
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Article
Reduced expression and rare genomic alteration of nm23-H1in human hepatocellular carcinoma and hepatoma cell lines
We investigated the expression and genomic alteration of nm23-H1 (which encodes a nucleoside diphosphate, kinase A) in 12 human hepatocellular carcinomas (HCCs) and four hepatoma cell lines. The expression of nm...
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Chapter and Conference Paper
Continuous Operation of Olive Oil Hydrolysis with Lipase in “Vibro Mixer”
A two-phase enzymatic reaction system has recently become of interest since a variety of oil soluble compounds was usable as a substrate[1]. A number of oil and fat are water-immiscible liquid or solid. Their ...
