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Article
Open AccessDifferential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer
Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts...
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Article
Open AccessTGF-β1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels
Apoptosis of fibroblasts may be key for the removal of cells following repair processes. Contraction of three-dimensional collagen gels is a model of wound healing and remodeling. Here two potent inducers of c...
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Article
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present study was designed to evaluate the...
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Article
Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels
Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensio...