-
Article
Open AccessMetastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer
Circulating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal ca...
-
Article
Open AccessInhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells
Human amniotic epithelial cells (hAECs), which are a type of placental stem cell, express stem cell marker genes and are capable of differentiating into all three germ layers under appropriate culture conditio...
-
Article
Open AccessTGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma
Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator o...
-
Article
Open AccessTargeting hepatocyte growth factor in epithelial–stromal interactions in an in vitro experimental model of human periodontitis
Periodontitis is a chronic inflammatory disease leading to progressive connective tissue degradation and loss of the tooth-supporting bone. Clinical and experimental studies suggest that hepatocyte growth fact...
-
Article
Anatomic femoral tunnel placement is difficult by the transtibial technique: comparison of three different femoral tunnel drilling techniques in double-bundle anterior cruciate ligament reconstructions
To compare the position and direction of femoral and tibial tunnels for both the anteromedial bundle (AMB) and posterolateral bundle (PLB) among three different femoral tunnel drilling techniques, transtibial ...
-
Article
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development
Lung cancer is one of the major causes of cancer death and clarification of its molecular pathology is highly prioritized. The physiological importance of mRNA degradation through the CCR4-NOT deadenylase has ...
-
Article
Risk factors for residual pivot shift after anterior cruciate ligament reconstruction: data from the MAKS group
To investigate the risk factors for residual pivot shift test after anterior cruciate ligament (ACL) reconstruction based on a multicenter prospective cohort study.
-
Article
Lateral meniscus posterior root tear contributes to anterolateral rotational instability and meniscus extrusion in anterior cruciate ligament-injured patients
The purposes of this study were to investigate (1) meniscus status and clinical findings in anterior cruciate ligament (ACL)-injured patients to clarify associations between the meniscus posterior root tear (P...
-
Article
Open AccessThe incidence and risk factors of asymptomatic primary spontaneous pneumothorax detected during health check-ups
Patients with primary spontaneous pneumothorax (PSP) usually complain of sudden-onset dyspnea and pleuritic chest pain. However, asymptomatic PSP has been incidentally detected on chest X-rays. In this study, ...
-
Article
Evaluation of pivot shift phenomenon while awake and under anaesthesia by different manoeuvres using triaxial accelerometer
Evaluating pivot shift phenomenon is difficult due to its subjectivity, wide variation of testing manoeuvres, and difficulty in evaluating patients while awake. The purpose of this study was to evaluate the p...
-
Article
Open AccessComplete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation
In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. One of the most important issues to ensuring clinica...
-
Article
Open AccessYields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients
Mesenchymal stem cells derived from the synovial membrane (synovial MSCs) are a candidate cell source for regenerative medicine of cartilage and menisci due to their high chondrogenic ability. Regenerative med...
-
Article
Open AccessTAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts
Transcriptional coactivator with PDZ-binding motif (TAZ) regulates a variety of biological processes. Nuclear translocation and activation of TAZ are regulated by multiple mechanisms, including actin cytoskele...
-
Article
In-vivo kinematics of high-flex posterior-stabilized total knee prosthesis designed for Asian populations
The purpose of this study was to determine in-vivo kinematics of our developed posterior-stabilized (PS) total knee prosthesis for Asian populations in comparison with a popular high-flexion PS prosthesis.
-
Article
Open AccessTranscriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis
Periodontitis is affecting over half of the adult population and represents a major public health problem. Previously, we isolated a subset of gingival fibroblasts (GFs) from periodontitis patients, designated...
-
Article
Behind-remnant arthroscopic observation and scoring of femoral attachment of injured anterior cruciate ligament
To describe the femoral anterior cruciate ligament (ACL) attachment based on the behind-remnant observation with a new scoring system and to investigate the characteristics of an ACL injured knee.
-
Article
A new behind-remnant approach for remnant-preserving double-bundle anterior cruciate ligament reconstruction compared with a standard approach
To introduce a new behind-remnant approach for double-bundle (DB) anterior cruciate ligament (ACL) reconstruction and to compare the femoral tunnel positions of anteromedial (AM) and posterolateral (PL) bundle...
-
Article
A modified quadrant method for describing the femoral tunnel aperture positions in ACL reconstruction using two-view plain radiographs
A modified quadrant method was developed for description of femoral tunnel aperture positions on the sagittal plane after double-bundle anterior cruciate ligament (ACL) reconstruction, which can be measured by...
-
Article
Effect of femoral tunnel position on graft tension curves and knee stability in anatomic double-bundle anterior cruciate ligament reconstruction
To evaluate the effect of the femoral tunnel position of the anteromedial bundle (AMB) and the posterolateral bundle (PLB) on the graft tension curves and knee stability in anatomic double-bundle anterior cru...
-
Article
Open AccessDifferential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer
Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts...
