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  1. Article

    Open Access

    Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer

    Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts...

    Masafumi Horie, Akira Saito, Satoshi Noguchi, Yoko Yamaguchi… in BMC Cancer (2014)

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  2. No Access

    Article

    Histamine stimulates human lung fibroblast migration

    Histamine is a potent mediator in allergic inflammatory processes and is released by basophils and mast cells. The aim of this study was to investigate the effect of histamine on in vitro migration of human fe...

    Tadashi Kohyama, Yasuhiro Yamauchi, Hajime Takizawa… in Molecular and Cellular Biochemistry (2010)

  3. No Access

    Article

    Procaterol Inhibits Lung Fibroblast Migration

    Fibroblasts are important cells that are involved in modulation of fibrosis after injuries. In some uncontrollable inflammatory processes, excess fibroblasts migrate around the small airway. The pathogenesis o...

    Tadashi Kohyama, Yasuhiro Yamauchi, Hajime Takizawa, Susumu Itakura… in Inflammation (2009)

  4. Article

    Open Access

    TGF-β1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels

    Apoptosis of fibroblasts may be key for the removal of cells following repair processes. Contraction of three-dimensional collagen gels is a model of wound healing and remodeling. Here two potent inducers of c...

    Tetsu Kobayashi, **angde Liu, Hui Jung Kim, Tadashi Kohyama… in Respiratory Research (2005)

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  5. No Access

    Article

    IL-4 and IL-13 Induce Chemotaxis of Human Foreskin Fibroblasts, But Not Human Fetal Lung Fibroblasts

    Through shared receptors, IL-4 and IL-13 have been suggested to regulate not only inflammatory cells, but also to play a role in stimulating fibroblasts during fibrotic processes. Previous studies have shown t...

    Tadashi Kohyama, **angde Liu, Fu-Qiang Wen, Tetsu Kobayashi, Shinji Abe… in Inflammation (2004)

  6. No Access

    Article

    Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells

    Cell migration and matrix remodeling are key events in tissue repair and restructuring. Osteoblasts are responsible for the production of new bone matrix during bone remodeling. The activity of these cells can...

    **angde Liu, Tadashi Kohyama, Tetsu Kobayashi, Shinji Abe… in Osteoporosis International (2003)

  7. No Access

    Article

    Glucocorticoids Modulate TGF-β Production by Human Fetal Lung Fibroblasts

    TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGF-β isoforms a...

    Fu-Qiang Wen, Tadashi Kohyama, C. Magnus Sköld, Yun Kiu Zhu, **angde Liu… in Inflammation (2003)

  8. No Access

    Article

    Glucocorticoids Modulate TGF-β Production

    TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-β isoforms a...

    Fu-Qiang Wen, Tadashi Kohyama, C. Magnus Sköld, Yun Kiu Zhu, **angde Liu… in Inflammation (2002)

  9. Article

    Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture

    Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present study was designed to evaluate the...

    Yunkui Zhu, C Magnus Sköld, **angde Liu, Hangjun Wang… in Respiratory Research (2001)

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  10. Article

    Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels

    Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensio...

    Yunkui Zhu, **angde Liu, C Magnus Sköld, Hangjun Wang… in Respiratory Research (2001)

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  11. No Access

    Article

    Glucocorticoids and TGF-β1 Synergize in Augmenting Fibroblast Mediated Contraction of Collagen Gels

    TGF-β plays a central role in the initiation and progression of pulmonary fibrosis. Glucocorticoids are frequently used to treat fibrotic diseases, but beneficial effects are often modest. Both TGF-β and gluco...

    Fu-Qiang Wen, C. Magnus Sköld, **ang-Der Liu, Ronald F. Ertl, Yun Kui Zhu… in Inflammation (2001)