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Article
Open AccessMammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors
Despite limited reports on glutamine methylation, methylated glutamine is found to be highly conserved in a "GGQ" motif in both prokaryotes and eukaryotes. In bacteria, glutamine methylation of peptide chain r...
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Article
Open AccessThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first ...
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Article
Open AccessTri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8
G9a and the related enzyme GLP were originally identified as histone lysine methyltransferases and then shown to also methylate several other non-histone proteins.
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Article
Open AccessRole of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions
METTL20 is a seven-β-strand methyltransferase that is localised to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) β subunit (ETFB) at lysines 200 and 203. It has been shown that M...
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Article
Erratum: Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines
Correction to: The Journal of Antibiotics (2012) 65, 263–265; doi:10.1038/ja.2012.6; published online 15 February 2012 Due to a typesetting error, in Figure 1, (e) and (f) were published incorrectly. Productio...
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Article
Open AccessEnhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
Although heat-shock protein 70 (HSP70), an evolutionarily highly conserved molecular chaperone, is known to be post-translationally modified in various ways such as phosphorylation, ubiquitination and glycosyl...
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Article
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines
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Article
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
The sirtuin family of regulatory proteins has been implicated in various biological pathways including responses to calorie restriction and metabolic stress. Work in mice now shows that sirtuin 3 (SIRT3), whic...
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Article
Self-activation of Serine/Threonine Kinase AfsK on Autophosphorylation at Threonine-168
A Hanks-type protein kinase AfsK autophosphorylates on threonine residue(s) and phosphorylates AfsR, a global regulator for secondary metabolism in Streptomyces coelicolor A3(2). Mass spectrometry of a tryptic di...
