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Article
Open AccessGeneration of a novel transgenic rat model for tracing extracellular vesicles in body fluids
Extracellular vesicles (EVs) play an important role in the transfer of biomolecules between cells. To elucidate the intercellular transfer fate of EVs in vivo, we generated a new transgenic (Tg) rat model using g...
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Article
Open AccessAn in vitro reproduction of stress-induced memory defects: Effects of corticoids on dendritic spine dynamics
Previously, in organotypic slice culture of rodent hippocampus we found that three repeated inductions of LTP, but not a single induction, led to a slow-develo** long-lasting enhancement of synaptic strength...
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Article
Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet
High-fat diet (HFD) has been recently reported to induce sensorimotor gating deficits, but the underlying mechanisms are not well understood.
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Article
Open AccessGlucocorticoid affects dendritic transport of BDNF-containing vesicles
Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation and functions in the central nervous system (CNS). Because BDNF protein is sorted into secretory vesicles at the tra...
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Article
Impairments in Brain-Derived Neurotrophic Factor-Induced Glutamate Release in Cultured Cortical Neurons Derived from Rats with Intrauterine Growth Retardation: Possible Involvement of Suppression of TrkB/Phospholipase C-γ Activation
Low birth weight due to intrauterine growth retardation (IUGR) is suggested to be a risk factor for various psychiatric disorders such as schizophrenia. It has been reported that developmental cortical dysfun...
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Article
Behavioral and molecular evidence for psychotropic effects in l-theanine
l-Theanine (N-ethyl-l-glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamater...
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Article
Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling
Dopamine agonists have been implicated in the treatment of depression. Cabergoline is an ergot derivative with a high affinity to dopamine D2-like receptors; however, there have been few preclinical studies on it...
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Article
Genetic Variations of Human Neuropsin Gene and Psychiatric Disorders: Polymorphism Screening and Possible Association with Bipolar Disorder and Cognitive Functions
Human neuropsin (NP) (hNP) has been implicated in the progressive change of cognitive abilities during primate evolution. The hNP gene maps to chromosome 19q13, a region reportedly linked to schizophrenia and ...
