27 Result(s)
-
Chapter
Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen
The influence of bivalent manganese ions (Mn++ ) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-...
-
Article
Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen
The influence of bivalent manganese ions (Mn++) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-f...
-
Article
Über den Einfluß von Mn++-Ionen auf die positiv inotrope Wirkung einiger Pharmaka an isolierten Meerschweinchenvorhöfen
-
Article
Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle
The effects of dibutyryl cyclic AMP (DB-AMP; 10−3M) and adrenaline (2.2×10−6 M) on contractile force, 45Ca uptake, and total myocardial Ca concentration were investigated in electrically driven left auricles isol...
-
Article
Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides
This study was designed to further elucidate relevance and mechanism of the positive inotropic action of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP). For this purpose the effects of cyclic N6-monobutyryl-AMP (N6-MB-c...
-
Article
Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation
The effects of adrenaline (2.2×10−6 M) and cyclic N6-2′-O-dibutyryl-adenosine-3′,5′-monophosphate (DB-c-AMP; 10−3 M) on mechanical performance, 45Ca uptake and total tissue calcium concentration were investigated...
-
Article
Adrenaline, DB-c-AMP and myocardial 45Ca exchange. Comparative studies in rat and guinea-pig auricles
The positive inotropic effect of adrenaline has been assumed to result from an increase in the intracellular level of c-AMP which, in turn, might enhance the permeability of the cardiac cell membrane to Ca2+. In ...
-
Article
Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species
Conflicting results exist about the influence of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP) on myocardial contractile force. The present study was designed to examine whether the positive inotropic action of DB-c-AM...
-
Article
Pharmacokinetic analysis of the interaction between dicoumarol and tolbutamide in man
The effect of repeated administration of tolbutamide on the elimination and anticoagulant action of a single oral dose of dicoumarol 600 mg was studied in four healthy male subjects using a crossover design. I...
-
Chapter
Anticoagulant Activity of the Enantiomers of Acenocoumarol in Man
For the mono-coumarin derivatives warfarin and phen-procoumon it was shown that in man and rats the S(−) enantiomer is several times more potent as anticoagulant than the R(+) enantiomer. These stereoselective...
-
Article
Haemodynamic effects of a single intravenous dose of lorcainide in patients with heart disease
The cardiovascular effects of a single i.v. dose (2 mg/kg over 5 min) of lorcainide were studied in 14 patients with heart disease. In the haemodynamic part of the study (6 patients), the aortic and pulmonary ...
-
Article
Disposition of azapropazone in chronic renal and hepatic failure
The disposition of azapropazone 600 mg i.v. was investigated in 6 healthy subjects, 13 patients with cirrhosis and 8 patients with renal failure. In healthy subjects the elimination half-life was 12.2±2.1 h (m...
-
Chapter
Echocardiographic Studies in Cardiomyopathies
Cardiomyopathies comprise a large and inhomogenous group of myocardial diseases. The term primary cardiomyopathy has been proposed for those cases in which a causal factor could not be found.
-
Chapter
Isosorbide Dinitrate: Pharmacokinetics After Intravenous Administration
Isosorbide dinitrate (ISDN) is an important organic nitrate found therapeutically useful in its sublingual and oral forms in various cardiovascular diseases such as angina pectoris (1) and congestive heart fai...
-
Chapter
Computertomographic Findings in Congestive Cardiomyopathy
The contribution of non-invasive radiologic diagnostic procedures has thus far been rather insignificant in the diagnosis of cardiomyopathy. The mainstay has been the conventional chest X-ray. Estimation of di...
-
Chapter
Prevalence of Arrhythmias During 24-Hour Electrocardiographic Monitoring in Patients with Dilative Cardiomyopathy
Clinical symptoms of dilative (congestive) cardiomyopathy (DCM) were generally attributed to left ventricular pump failure or thromboembolic complications. Only sporadic reports appeared documenting arrhythmia...
-
Chapter
Repetitive Response to Ventricular Extrastimuli in Patients with Dilated Cardiomyopathy
In dilated cardiomyopathy ventricular arrhythmias are frequently observed and may lead to sudden death from ventricular fibrillation [2, 3, 5]. Increased ventricular vulnerability therefore seems to exist in s...
-
Chapter
Biochemical Findings in Serum of Patients with Congestive Cardiomyopathy: Is Serum Selenium Concentration a Possible Marker?
The conventional methods of clinical chemistry, such as determination of enzyme activities in serum, are not suited for diagnosis or differential diagnosis of cardiomyopathy. Only in a few cases have we observ...
-
Article
Experience in the Long Term Use of New Antiarrhythmic Drugs
-
Chapter and Conference Paper
Akutwirkungen der neuen inotropen Substanz OPC-8212
In den letzten Jahren sind zahlreiche inotrop wirkende Pharmaka zur Therapie der Herzinsuffizienz entwickelt worden [5]. Aus klinischer Sicht sind besonders diejenigen Substanzen von Interesse, welche für die ...
