27 Result(s)
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Article
Digitoxin intoxication during concomitant use of amiodarone
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Article
The acute effects of intravenously administered mibefradil, a new calcium antagonist, on the electrophysiologic characteristics of the human heart
Objective : This multicenter, double-blind, placebo-controlled, parallel-group study was designed to assess the acute effects of intravenous mibefradil on the electrophysiologic characte...
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Article
Cilazapril in Congestive Heart Failure
The haemodynamic effects of a single dose of cilazapril 2.5 or 5mg were studied in 33 patients with stable chronic congestive heart failure who were receiving digitalis and diuretics. Subsequently, a double-bl...
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Chapter and Conference Paper
Indikationsbereiche von Klasse-I-Antiarrhythmika — differentialtherapeutische Aspekte bei ventrikulären Herzrhythmusstörungen
Während Anfang der achtziger Jahre die prognostische Bedeutung ventrikulärer Arrhythmieformen als weitgehend gesichert angesehen und eine entsprechende antiarrhythmischen Therapie verhältnismäßig freizügig geh...
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Chapter and Conference Paper
Calcium Antagonists in Silent Myocardial Ischemia — Preliminary Results with Nisoldipine
The use of calcium channel blockers was shown to be effective in the treatment of symptomatic and, more recently, of asymptomatic myocardial ischemia. In this continuing study we evaluated the efficacy of niso...
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Article
Factors responsible for interindividual differences in the dose requirement of phenprocoumon
The total and unbound plasma concentrations of phenprocoumon and the prothrombin complex activity were determined in 51 patients on phenprocoumon.
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Chapter
Grundlagen der Wirkung sympathikomimetischer Stoffe
Im nachfolgenden Kapitel werden zunächst einige für die klinische Praxis relevante Wirkungen sympathikomimetischer Stoffe an Organsystemen beschrieben und entsprechend ihren Angriffsorten eingeteilt und charak...
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Chapter and Conference Paper
Akutwirkungen der neuen inotropen Substanz OPC-8212
In den letzten Jahren sind zahlreiche inotrop wirkende Pharmaka zur Therapie der Herzinsuffizienz entwickelt worden [5]. Aus klinischer Sicht sind besonders diejenigen Substanzen von Interesse, welche für die ...
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Article
Experience in the Long Term Use of New Antiarrhythmic Drugs
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Chapter
Echocardiographic Studies in Cardiomyopathies
Cardiomyopathies comprise a large and inhomogenous group of myocardial diseases. The term primary cardiomyopathy has been proposed for those cases in which a causal factor could not be found.
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Chapter
Isosorbide Dinitrate: Pharmacokinetics After Intravenous Administration
Isosorbide dinitrate (ISDN) is an important organic nitrate found therapeutically useful in its sublingual and oral forms in various cardiovascular diseases such as angina pectoris (1) and congestive heart fai...
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Chapter
Computertomographic Findings in Congestive Cardiomyopathy
The contribution of non-invasive radiologic diagnostic procedures has thus far been rather insignificant in the diagnosis of cardiomyopathy. The mainstay has been the conventional chest X-ray. Estimation of di...
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Chapter
Prevalence of Arrhythmias During 24-Hour Electrocardiographic Monitoring in Patients with Dilative Cardiomyopathy
Clinical symptoms of dilative (congestive) cardiomyopathy (DCM) were generally attributed to left ventricular pump failure or thromboembolic complications. Only sporadic reports appeared documenting arrhythmia...
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Chapter
Repetitive Response to Ventricular Extrastimuli in Patients with Dilated Cardiomyopathy
In dilated cardiomyopathy ventricular arrhythmias are frequently observed and may lead to sudden death from ventricular fibrillation [2, 3, 5]. Increased ventricular vulnerability therefore seems to exist in s...
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Chapter
Biochemical Findings in Serum of Patients with Congestive Cardiomyopathy: Is Serum Selenium Concentration a Possible Marker?
The conventional methods of clinical chemistry, such as determination of enzyme activities in serum, are not suited for diagnosis or differential diagnosis of cardiomyopathy. Only in a few cases have we observ...
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Article
Disposition of azapropazone in chronic renal and hepatic failure
The disposition of azapropazone 600 mg i.v. was investigated in 6 healthy subjects, 13 patients with cirrhosis and 8 patients with renal failure. In healthy subjects the elimination half-life was 12.2±2.1 h (m...
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Article
Haemodynamic effects of a single intravenous dose of lorcainide in patients with heart disease
The cardiovascular effects of a single i.v. dose (2 mg/kg over 5 min) of lorcainide were studied in 14 patients with heart disease. In the haemodynamic part of the study (6 patients), the aortic and pulmonary ...
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Chapter
Anticoagulant Activity of the Enantiomers of Acenocoumarol in Man
For the mono-coumarin derivatives warfarin and phen-procoumon it was shown that in man and rats the S(−) enantiomer is several times more potent as anticoagulant than the R(+) enantiomer. These stereoselective...
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Article
Pharmacokinetic analysis of the interaction between dicoumarol and tolbutamide in man
The effect of repeated administration of tolbutamide on the elimination and anticoagulant action of a single oral dose of dicoumarol 600 mg was studied in four healthy male subjects using a crossover design. I...
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Article
Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species
Conflicting results exist about the influence of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP) on myocardial contractile force. The present study was designed to examine whether the positive inotropic action of DB-c-AM...
