18 Result(s)
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Article
Digitoxin intoxication during concomitant use of amiodarone
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Article
The acute effects of intravenously administered mibefradil, a new calcium antagonist, on the electrophysiologic characteristics of the human heart
Objective : This multicenter, double-blind, placebo-controlled, parallel-group study was designed to assess the acute effects of intravenous mibefradil on the electrophysiologic characte...
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Chapter and Conference Paper
Calcium Antagonists in Silent Myocardial Ischemia — Preliminary Results with Nisoldipine
The use of calcium channel blockers was shown to be effective in the treatment of symptomatic and, more recently, of asymptomatic myocardial ischemia. In this continuing study we evaluated the efficacy of niso...
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Article
Factors responsible for interindividual differences in the dose requirement of phenprocoumon
The total and unbound plasma concentrations of phenprocoumon and the prothrombin complex activity were determined in 51 patients on phenprocoumon.
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Chapter
Grundlagen der Wirkung sympathikomimetischer Stoffe
Im nachfolgenden Kapitel werden zunächst einige für die klinische Praxis relevante Wirkungen sympathikomimetischer Stoffe an Organsystemen beschrieben und entsprechend ihren Angriffsorten eingeteilt und charak...
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Chapter and Conference Paper
Akutwirkungen der neuen inotropen Substanz OPC-8212
In den letzten Jahren sind zahlreiche inotrop wirkende Pharmaka zur Therapie der Herzinsuffizienz entwickelt worden [5]. Aus klinischer Sicht sind besonders diejenigen Substanzen von Interesse, welche für die ...
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Article
Disposition of azapropazone in chronic renal and hepatic failure
The disposition of azapropazone 600 mg i.v. was investigated in 6 healthy subjects, 13 patients with cirrhosis and 8 patients with renal failure. In healthy subjects the elimination half-life was 12.2±2.1 h (m...
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Article
Haemodynamic effects of a single intravenous dose of lorcainide in patients with heart disease
The cardiovascular effects of a single i.v. dose (2 mg/kg over 5 min) of lorcainide were studied in 14 patients with heart disease. In the haemodynamic part of the study (6 patients), the aortic and pulmonary ...
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Chapter
Anticoagulant Activity of the Enantiomers of Acenocoumarol in Man
For the mono-coumarin derivatives warfarin and phen-procoumon it was shown that in man and rats the S(−) enantiomer is several times more potent as anticoagulant than the R(+) enantiomer. These stereoselective...
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Article
Pharmacokinetic analysis of the interaction between dicoumarol and tolbutamide in man
The effect of repeated administration of tolbutamide on the elimination and anticoagulant action of a single oral dose of dicoumarol 600 mg was studied in four healthy male subjects using a crossover design. I...
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Article
Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species
Conflicting results exist about the influence of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP) on myocardial contractile force. The present study was designed to examine whether the positive inotropic action of DB-c-AM...
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Article
Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation
The effects of adrenaline (2.2×10−6 M) and cyclic N6-2′-O-dibutyryl-adenosine-3′,5′-monophosphate (DB-c-AMP; 10−3 M) on mechanical performance, 45Ca uptake and total tissue calcium concentration were investigated...
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Article
Adrenaline, DB-c-AMP and myocardial 45Ca exchange. Comparative studies in rat and guinea-pig auricles
The positive inotropic effect of adrenaline has been assumed to result from an increase in the intracellular level of c-AMP which, in turn, might enhance the permeability of the cardiac cell membrane to Ca2+. In ...
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Article
Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides
This study was designed to further elucidate relevance and mechanism of the positive inotropic action of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP). For this purpose the effects of cyclic N6-monobutyryl-AMP (N6-MB-c...
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Article
Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle
The effects of dibutyryl cyclic AMP (DB-AMP; 10−3M) and adrenaline (2.2×10−6 M) on contractile force, 45Ca uptake, and total myocardial Ca concentration were investigated in electrically driven left auricles isol...
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Article
Über den Einfluß von Mn++-Ionen auf die positiv inotrope Wirkung einiger Pharmaka an isolierten Meerschweinchenvorhöfen
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Article
Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen
The influence of bivalent manganese ions (Mn++) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-f...
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Chapter
Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen
The influence of bivalent manganese ions (Mn++ ) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-...
