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Article
Pegfilgrastim, a sustained-duration form of filgrastim, significantly improves neutrophil recovery after autologous marrow transplantation in rhesus macaques
Daily administration of filgrastim decreases the duration of severe neutropenia in the clinical setting. A sustained-duration form of filgrastim, pegfilgrastim, significantly reduces scheduling protocols to a ...
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Article
Mast cell growth factor (C-Kit Ligand) in combination with granulocyte-macrophage colony-stimulating factor and interleukin-3:in vivo hemopoietic effects in irradiated mice compared toin vitro effects
In the presence of hemopoietic cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem cell factor, ...
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Chapter
Cytokines Interaction in Innate and Immunomodulator-Induced Radioprotection
Ionizing radiation is particularly damaging to lymphoid and hematopoietic tissues, leading to anemia and decreased resistance to opportunistic infections, often resulting in death (1). Enhancing host defenses ...
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Chapter
Cytokine Treatment of Radiation-Induced Hemopoietic Suppression: Results of Interleukin-6 and Granulocyte Colony-Stimulating Factor in a Murine Radiation Model
Following accidental radiation exposure or intensive radiotherapy severe hemopoietic depression often results from damage to hemopoietic stem and progenitor cell populations. The major risks of mortality follo...
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Chapter
Synergy between G-CSF and WR-2721: Effects on Enhancing Hemopoietic Reconstitution and Increasing Survival Following Exposure to Ionizing Radiation
WR-2721 is one of the most effective exogenous radioprotectants discovered (1, 2). Mechanisms through which WR-2721 protects cells from radiation-induced lethality include free radical scavenging, hydrogen ato...
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Article
Utility of interleukin-1 in therapy of radiation injury as studied in small and large animal models
Our results demonstrate that IL-1 promotes hematopoiesis in normal and radiation compromised animals. IL-1 protected mice from lethal hematopoietic syndrome when given before irradiation. Given after irradiati...
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Article
Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells
Glucan, a beta-1, 3 polyglucose, was administered to mice either 1 h before or 1 h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistantly exhibited a ...
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Book
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Chapter
Response of Different Species to High Dose Total Body Irradiation
During the past decade, relatively few new studies have been initiated on the response of different species to high-dose, total-body irradiation. For information on the LD5q/30d (the dose produces 50 percent leth...
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Chapter
Summary of Round Table Discussion on Response of Different Species
In preparing the workshop the organizers formulated a number of key questions which were considered to be of great relevance to the subject. Under the chairmanship of van Bekkum the following four items were c...
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Chapter
Acute Lethality and Radiosensitivity of the Canine Hemopoietic System to Cobalt-60 Gamma and Mixed Neutron-Gamma Irradiation
Extrapolation of data obtained from model animal systems to predict the human biological response to ionizing radiation and subsequent stressors, such as trauma and/or infectious disease, remains a difficult p...
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Article
Hemopoiesis in pregnant beagles following low-dose total-body irradiation and surgery
Hemopoietic perturbations were observed in gravid beagles subjected to whole-body ionizing radiation during midpregnancy followed by the additional trauma of surgery, with alterations in peripheral blood hemog...
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Chapter
Inflammatory Response of LPS-Hyporesponsive and LPS-Responsive Mice to Challenge with Gram-Negative Bacteria Salmonella Typhimurium and Klebsiella Pneumoniae
The murine response to lipopolysaccharide (LPS) or endotoxin is determined by the allelic form of the Lps gene carried by the host (1,2). Mice that are homozygous for the defective Lps d allele, s...
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Chapter and Conference Paper
Alterations Induced in Murine Hemopoietic Stem Cells Following a Single Injection of Corynebacterium parvum
Corynebacterium parvum is one of several agents shown to have marked anti-tumor activity (10,20). The tumor growth-inhibiting activity has been associated with the ability of C. parvum to stimulate the mononuclea...
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Chapter and Conference Paper
Colony-forming Cells in the Thymus and Mesenteric Lymph Nodes of Mice Engrafted with Lewis Lung Carcinoma Cells
The in vitro culture of granulocyte-macrophage progenitor cells from a number of anatomical sites of the mouse apparently results in the clonal growth of at least two subpopulations of cells. One subpopulation, c...
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Chapter
Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells Detected within Mouse Thymus and Lymph Nodes
The population of in vitro colony-forming cells (CFU-c) has been found to be heterogeneous with respect to several characteristic parameters such as buoyant density (10, 21, 32), sedimentation rate (29), adherenc...
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Chapter and Conference Paper
Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells Detected within Mouse Thymus and Lymph Nodes
The population ofin vitro colony-forming cells (CFU-c) has been found to be heterogeneous with respect to several characteristic parameters such as buoyant density (10, 21, 32), sedimentation rate (29), adherence...
