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Open AccessLipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins
Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid enviro...
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Article
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids—a palmitoyl group at the N terminus and a cholesteroyl group at the C terminus. W...
