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  1. No Access

    Article

    Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

    The nuclear factor (NF)-κB transcription factor has essential roles in inflammation and oncogenesis. Its ubiquitous RelA subunit is regulated by several post-translational modifications, including phosphorylat...

    H Li, T Wittwer, A Weber, H Schneider, R Moreno, G N Maine, M Kracht in Oncogene (2012)

  2. No Access

    Chapter and Conference Paper

    Local Gravity Field Modelling in Rugged Terrain Using Spherical Radial Basis Functions: Case Study for the Canadian Rocky Mountains

    We analyze the performance of a least-squares approximation of the gravity field using Spherical Radial Basis Functions (SRBFs) in rugged mountains. The numerical experiment is conducted for the gravity distur...

    R. Tenzer, R. Klees, T. Wittwer in Geodesy for Planet Earth (2012)

  3. No Access

    Chapter and Conference Paper

    Comparison of Regional and Global GRACE Gravity Field Models at High Latitudes

    In this study we address the question of whether regional gravity field modeling techniques of GRACE data can offer improved resolution over traditional global spherical harmonic solutions. Earlier studies int...

    B. C. Gunter, T. Wittwer, W. Stolk, R. Klees, P. Ditmar in Geodesy for Planet Earth (2012)

  4. No Access

    Chapter and Conference Paper

    Comparison of Techniques for the Computation of a Height Reference Surface from Gravity and GPS-Levelling Data

    Three different techniques for quasigeoid modelling from gravity and GPS-levelling data are compared: (i) a penalized least-squares technique using spherical radial basis functions provides a gravimetric quasi...

    R Tenzer, R Klees, I Prutkin, T Wittwer, B Alberts in Observing our Changing Earth (2009)

  5. Article

    Open Access

    A Comparison of Global and Regional GRACE Models for Land Hydrology

    When using GRACE as a tool for hydrology, many different gravity field model products are now available to the end user. The traditional spherical harmonics solutions produced from GRACE are typically obtained...

    R. Klees, X. Liu, T. Wittwer, B. C. Gunter, E. A. Revtova in Surveys in Geophysics (2008)

  6. Article

    Open Access

    A data-driven approach to local gravity field modelling using spherical radial basis functions

    We propose a methodology for local gravity field modelling from gravity data using spherical radial basis functions. The methodology comprises two steps: in step 1, gravity data (gravity anomalies and/or gravi...

    R. Klees, R. Tenzer, I. Prutkin, T. Wittwer in Journal of Geodesy (2008)

  7. No Access

    Chapter

    A data-adaptive design of a spherical basis function network for gravity field modelling

    A data-adaptive strategy for the design of spherical basis function (SBF) networks is presented. The strategy comprises a data-driven selection of the SBFs prior to parameter estimation and an automatic select...

    R. Klees, T. Wittwer in Dynamic Planet (2007)

  8. No Access

    Chapter

    Local gravity field modelling with multi-pole wavelets

    We propose an alternative approach to the application of spherical wavelet functions for local gravity field modelling from terrestrial, airborne and/or space-borne data. Instead of estimating the finest scale...

    R. Klees, T. Wittwer in Dynamic Planet (2007)

  9. No Access

    Chapter and Conference Paper

    DHEA wirkt protektiv bei einer experimentellen polymikrobiellen Sepsis durch CLP — besteht eine pathogenetische Bedeutung des TNF-α?

    Sepsis is a frequent complication in the posttraumatic course on the intensive care unit. Cytokines play an important role. High levels of TNF-α correspond to bad prognosis. The main effects of TNF-α during se...

    Dr. M. van Griensven, T. Wittwer, N. Brauer in Chirurgisches Forum 2001 für experimentell… (2001)

  10. No Access

    Article

    Minimalinvasive Revaskularisation der Vorderwand mittels Mammaria-Bypass am schlagenden Herzen

    The value of minimally invasive techniques in relation to conventional coronary surgery is not clearly established and frequently very controversially discussed.

    J. Cremer, T. Wittwer, A. Böning, M. Anssar, T. Kofidis in Zeitschrift für Kardiologie (1999)

  11. No Access

    Article

    Hybrid-Verfahren zur Myokardrevaskularisation: Stellenwert der Kombination von minimal-invasiver Bypasstechnik (MIDCAB) mit interventioneller Therapie (PTCA)

    Background: Minimally invasive direct coronary artery bypass (MIDCAB) grafting without cardipulmonary bypass (CPB) through an anterolateral minithoracotomy has become a promising therapeutical option especially ...

    T. Wittwer, J. Cremer, T. Wahlers, A. Mügge, B. Heublein in Zeitschrift für Kardiologie (1999)

  12. No Access

    Chapter and Conference Paper

    Minimal invasive Bypassoperationen am schlagenden Herzens und Anwendung einer mechanischen Stabilisierung der Herzoberfläche

    Different minimally invasive techniques are currently being controversially discussed among cardiac surgeons. For revascularization of anterior myocardial vessels, off-bypass procedures were performed in 64 ca...

    J. Cremer, M. Strüber, T. Wittwer in Klinik und Forschung in der Chirurgie unte… (1997)