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Article
Cross resistance and cellular uptake of 4′-O-methyldoxorubicin in experimental tumors with acquired resistance to doxorubicin
A new analog of doxorubicin, 4′-O-methyldoxorubicin, was previously reported to have a pronounced activity agianst L1210 leukemia, which shows a natural partial resistance to doxorubicin itself. In the present...
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Article
In vitro and in vivo study of cross resistance between daunorubicin and daunorubicin-DNA complex in Ehrlich ascites tumor
The antitumor effect of daunorubicin and of two preparations of daunorubicin-DNA complexes were compared in equitoxic doses against the Ehrlich ascites tumor and in a subline of this tumor resistant to daunoru...