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  1. Article

    Open Access

    Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers

    Endostatin, a fragment of collagen XVIII, is an endogenous angiogenesis inhibitor with anti-tumour functions. However, elevated circulating endostatin concentrations have been found in several human cancers in...

    T Kantola, J P Väyrynen, K Klintrup, J Mäkelä, S M Karppinen in British Journal of Cancer (2014)

  2. Article

    Open Access

    Reply: Comment on 'Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma'

    T Kantola, K Klintrup, J P Väyrynen, J Vornanen, R Bloigu in British Journal of Cancer (2013)

  3. Article

    Open Access

    Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma

    Inflammation contributes to the pathogenesis of colorectal cancer (CRC), and cytokine levels are altered during colorectal carcinogenesis.

    T Kantola, K Klintrup, J P Väyrynen, J Vornanen, R Bloigu in British Journal of Cancer (2012)

  4. Article

    Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

    Eighteen patients with refractory and progressive solid tumors were treated with a single round of triple modified oncolytic adenovirus (Ad5/3-Cox2L-D24). Ad5/3-Cox2L-D24 is the first non-Coxsackie-adenovirus ...

    S Pesonen, P Nokisalmi, S Escutenaire, M Särkioja, M Raki, V Cerullo in Gene Therapy (2010)

  5. No Access

    Article

    Effect of fluconazole on plasma fluvastatin and pravastatin concentrations

    Objective: To study the effects of fluconazole on the pharmacokinetics of fluvastatin and pravastatin, two inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.

    T. Kantola, J. T. Backman, M. Niemi in European Journal of Clinical Pharmacology (2000)

  6. No Access

    Article

    Effect of itraconazole on cerivastatin pharmacokinetics

    Objective: To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) ...

    T. Kantola, K. T. Kivistö, P. J. Neuvonen in European Journal of Clinical Pharmacology (1999)