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Open AccessSerum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers
Endostatin, a fragment of collagen XVIII, is an endogenous angiogenesis inhibitor with anti-tumour functions. However, elevated circulating endostatin concentrations have been found in several human cancers in...
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Open AccessReply: Comment on 'Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma'
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Open AccessStage-dependent alterations of the serum cytokine pattern in colorectal carcinoma
Inflammation contributes to the pathogenesis of colorectal cancer (CRC), and cytokine levels are altered during colorectal carcinogenesis.
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Article
Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors
Eighteen patients with refractory and progressive solid tumors were treated with a single round of triple modified oncolytic adenovirus (Ad5/3-Cox2L-D24). Ad5/3-Cox2L-D24 is the first non-Coxsackie-adenovirus ...
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Article
Effect of fluconazole on plasma fluvastatin and pravastatin concentrations
Objective: To study the effects of fluconazole on the pharmacokinetics of fluvastatin and pravastatin, two inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.
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Article
Effect of itraconazole on cerivastatin pharmacokinetics
Objective: To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) ...