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Article
Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain
During catabolism of tryptophan through the kynurenine (KYN) pathway, several endogenous metabolites with neuromodulatory properties are produced, of which kynurenic acid (KYNA) is one of the highest significa...
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Article
Breaking the gene barrier in schizophrenia
Studies of schizophrenia have been plagued by shortcomings such as weak genetic association with disease, inadequate animal models and limited replication of gene expression findings. Future success may lie no...
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Article
Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the develo** human and murine brain
Herpes simplex viruses (HSV) produce age-dependent encephalitis characterized by more severe involvement of the cerebral cortex in younger hosts. To elucidate the potential role of the major neural entry recep...
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Article
Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development
Herpes simplex virus (HSV) is known to replicate within the limbic system and to alter behavior in both humans and experimental animals. However, the reason why the virus selectively damages this anatomical, d...
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Article
Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats
Rationale and objectives: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. Methods: Rat pups were injected twice daily with MK-8...
