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  1. Article

    Open Access

    Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer

    Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cance...

    Alexander Kretschmer, Fan Zhang, Syam Prakash Somasekharan… in Scientific Reports (2019)

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    Article

    Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes

    The assembly of large multimeric complexes in the crowded cytoplasm is challenging. Here we reveal a mechanism that ensures accurate production of the yeast proteasome, involving ribosome pausing and co-transl...

    Olesya O. Panasenko, Syam Prakash Somasekharan… in Nature Structural & Molecular Biology (2019)

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    Article

    eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

    Soluble oligomers of amyloid-β (Aβ) impair synaptic plasticity, perturb neuronal energy homeostasis, and are implicated in Alzheimer’s disease (AD) pathogenesis. Therefore, significant efforts in AD drug disco...

    Asad Jan, Brandon Jansonius, Alberto Delaidelli… in Acta Neuropathologica (2017)

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    Article

    TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis

    Recently, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) has been shown to be a potential candidate for cancer therapy. TRAIL induces apoptosis in various cancer cells but not in n...

    Syam Prakash Somasekharan, Michal Koc, Alexandre Morizot, Olivier Micheau… in Apoptosis (2013)