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Article

Autologous T cell therapy for MAGE-A4⁺ solid cancers in HLA-A*02⁺ patients: a phase 1 trial

Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma...

David S. Hong, Brian A. Van Tine, Swethajit Biswas, Cheryl McAlpine… in Nature Medicine (2023)