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Open AccessAutologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial
Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma...
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Article
Open AccessPharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study
In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of amyloid from liver, spleen and kidney in patients...
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Article
Non-glucose metabolism in cancer cells—is it all in the fat?
Cancer biologists seem to have overlooked tumor metabolism in their research endeavors over the last 80 years of the last century, only to have “rediscovered Warburg” (Warburg et al. 1930; Warburg, Science 123(31...
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Immunotherapeutic strategies in kidney cancer—when TKIs are not enough
The management of metastatic clear-cell renal-cell carcinoma has been revolutionized by the approval of targeted therapies. These targeted therapies have, however, been unable to provide robust complete respon...
