9 Result(s)
within
Suzan Wopereis
Human Genetics
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Article
Open AccessMulti-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge
A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultane...
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Article
Open AccessThe impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility
Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...
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Article
Open AccessPhenotypic flexibility as a measure of health: the optimal nutritional stress response test
Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life...
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Open AccessAssessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges
Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress res...
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Article
Open AccessVisualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes
Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the...
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Open AccessThe Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research
Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, ...
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Article
Open AccessChallenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioacti...
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Article
Open AccessInsight in modulation of inflammation in response to diclofenac intervention: a human intervention study
Chronic systemic low-grade inflammation in obese subjects is associated with health complications including cardiovascular diseases, insulin resistance and diabetes. Reducing inflammatory responses may reduce ...
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Article
MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers
The genes MBD1 and MBD2 encode methyl-CpG binding proteins that suppress transcription from methylated promoters. In contrast, CGBP encodes a protein that binds promoters containing unmethylated CpG and stimulate...
