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Article
Open AccessAssociations between adrenal gland volume and adipose tissue compartments – a whole body MRI study
Obesity is associated with alterations in the hypothalamic–pituitary–adrenal (HPA) axis. Effects of glucocorticoids on adipose tissues appear to depend on the specific adipose depot, in which they take place. ...
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Article
Open AccessMRI-based adrenal gland volume is associated with cardiovascular alterations in individuals without prior cardiovascular disease
Aim of this study was to analyse the associations of cardiovascular health and adrenal gland volume as a rather new imaging biomarker of chronic hypothalamic–pituitary–adrenal (HPA) axis activation. The study ...
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Article
Open AccessSerum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort
Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aim...
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Article
Open AccessAutomated image quality assessment for selecting among multiple magnetic resonance image acquisitions in the German National Cohort study
In magnetic resonance imaging (MRI), the perception of substandard image quality may prompt repetition of the respective image acquisition protocol. Subsequently selecting the preferred high-quality image data...
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Article
Open AccessAdipose tissue is associated with kidney function parameters
Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the ...
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Article
Open AccessAssociation of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study
To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD).
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Article
Open AccessHeterogeneity in coronary heart disease risk
There is large inter-individual heterogeneity in risk of coronary heart disease (CHD). Risk factors traditionally used in primary risk assessment only partially explain this heterogeneity. Residual, unobserved...
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Article
Open AccessImpact of prenatal and childhood adversity effects around World War II on multimorbidity: results from the KORA-Age study
While risk factors for age-related diseases may increase multimorbidity (MM), early life deprivation may also accelerate the development of chronic diseases and MM.
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Article
Open AccessDietary habits and the presence and degree of asymptomatic diverticular disease by magnetic resonance imaging in a Western population: a population-based cohort study
Despite the worldwide burden of diverticular disease, the connections between diverticular disease and dietary habits remain poorly understood, particularly in an asymptomatic representative sample. We investi...
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Article
Open AccessAssociated factors of white matter hyperintensity volume: a machine-learning approach
To identify the most important parameters associated with cerebral white matter hyperintensities (WMH), in consideration of potential collinearity, we used a data-driven machine-learning approach. We analysed ...
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Article
Open AccessAssociation of antecedent cardiovascular risk factor levels and trajectories with cardiovascular magnetic resonance-derived cardiac function and structure
The association of longitudinal trajectories of cardiovascular risk factors with cardiovascular magnetic resonance (CMR)-measures of cardiac structure and function in the community is not well known. Therefore...
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Article
Open AccessMachine-learning based exploration of determinants of gray matter volume in the KORA-MRI study
To identify the most important factors that impact brain volume, while accounting for potential collinearity, we used a data-driven machine-learning approach. Gray Matter Volume (GMV) was derived from magnetic...
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Article
Open AccessAssociation of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging
Elevated serum uric acid (SUA) is associated with a variety of medical conditions, such as hypertension, diabetes and obesity. Analyses investigating uric acid and obesity were primarily conducted using anthro...
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Article
Open AccessAssociation of longitudinal risk profile trajectory clusters with adipose tissue depots measured by magnetic resonance imaging
The objective of the study was to identify associations of longitudinal trajectories of traditional cardiometabolic risk factors with abdominal and ectopic adipose tissue depots measured by magnetic resonance ...
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Article
Open AccessGlucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart
Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United Stat...
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Article
Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population
Diverticular disease represents an increasing pathology and healthcare burden worldwide. Our aim was to study the prevalence, extent and distribution of asymptomatic diverticular disease assessed by magnetic r...
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Article
Open AccessAssociation of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study
Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morpholo...
