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Article
Open AccessCommissural misalignment independently predicts leaflet thrombosis after transcatheter aortic valve implantation
Transcatheter aortic valve implantation (TAVI) has become a minimally invasive alternative to surgical aortic valve replacement. Hypo-attenuated leaflet thickening (HALT)—a marker of subclinical leaflet thromb...
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Article
Open AccessInfluence of marginal incision and Le Fort I osteotomy on periodontal tissues: a prospective longitudinal study
The purpose of this prospective study was to evaluate whether the surgical protocol involving marginal incision and Le Fort I osteotomy affects the periodontal outcome. Twenty-nine patients requiring surgical ...
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Article
Open AccessThe SGLT2 inhibitor empagliflozin reduces tissue sodium content in patients with chronic heart failure: results from a placebo-controlled randomised trial
Sodium-glucose co-transporter 2 (SGLT2) inhibitors have cardiovascular protective properties in addition to the metabolic effects and represent a cornerstone of treating patients with chronic heart failure (CH...
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Open AccessRenal hemodynamic effects differ between antidiabetic combination strategies: randomized controlled clinical trial comparing empagliflozin/linagliptin with metformin/insulin glargine
Type 2 diabetes causes cardio-renal complications and is treated with different combination therapies. The renal hemodynamics profile of such combination therapies has not been evaluated in detail.
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Article
Open AccessClinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life
The aim of this study was to investigate the influence of clinical characteristics and dental restorative materials on oral health-related quality of life in patients with oral lichen planus. In particular, th...
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Article
Open AccessSimvastatin induces adverse effects on proliferation and mineralization of human primary osteoblasts
Frequently statins were administered to reduce the LDL-concentration in circulating blood. Especially simvastatin (SV) is an often prescribed statin. Pleiotropic effects of these drugs were reported. Thus, the...
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Article
Open AccessRetinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography
Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegene...
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Open Access4.6 Effects of Combined Therapy of Empagliflozin and Linagliptin Versus Metformin and Insulin Glargine on Blood Pressure and Vascular Function in Patients with Type 2 Diabetes
Combination of insulin with oral antidiabetic drugs is a valid option, but oral combination therapy emerged as an alternative treatment in type 2 diabetes (T2DM). However, the effects on blood pressure (BP) an...
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Article
Patient preference for therapies in hypertension: a cross-sectional survey of German patients
Hypertension is poorly controlled in numerous patients despite effective medication being available. Catheter-based renal denervation (RDN) has emerged as an alternative treatment option. We aimed to assess ho...
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Article
Mundgesundheitsbezogene Lebensqualität bei seltenen Erkrankungen im Zusammenhang mit oralen Symptomen, Diagnoseverzögerung und Geschlecht
In Deutschland sind rund 4 Mio. Menschen von verschiedenen seltenen Erkrankungen betroffen, von denen sich etwa 15 % im Zahn‑, Mund‑, Kiefer- und Gesichtsbereich manifestieren können.
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Article
Open AccessFast breakthrough of resistant cytomegalovirus during secondary letermovir prophylaxis in a hematopoietic stem cell transplant recipient
The compound letermovir (LMV) has recently been approved for the prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV seropositive recipients of an allogeneic hematopoietic stem cell transpl...
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Article
Open AccessHow does empagliflozin improve arterial stiffness in patients with type 2 diabetes mellitus? Sub analysis of a clinical trial
Empagliflozin has been shown to reduce cardiovascular mortality, but the underlying pathogenetic mechanisms are poorly understood. It was previously demonstrated that empagliflozin improved arterial stiffness.
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Article
Open AccessOral symptoms and oral health-related quality of life of individuals with x-linked hypophosphatemia
The primary purpose of this study was to collect data on the oral health-related quality of life (OHRQoL) of individuals with x-linked hypophosphatemia (XLH). It was also designed to gather information on the ...
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Article
Evaluation of the biocompatibility of root canal sealers on human periodontal ligament cells ex vivo
The aim of this study was to evaluate the biocompatibility of two comparatively new calcium silicate containing sealers (MTA-Fillapex and BioRoot-RCS) with that of two established sealers (AH-Plus, epoxy resin...
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Article
Open AccessThe micromass formation potential of human adipose-derived stromal cells isolated from different various origins
Adult stem cells appear to be a promising subject for tissue engineering, representing an individual material for regeneration of aged and damaged cells. Especially adipose derived stromal cells (ADSC), which ...
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Article
Open AccessEarly vascular parameters in the micro- and macrocirculation in type 2 diabetes
Diabetes converts from a metabolic disorder into a predominantly vascular disease, once its duration extends over several years or/and when additional cardiovascular risk factors such as hypertension coexist. ...
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Article
Open AccessPrimary failure of eruption (PFE): a systematic review
Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results ...
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Article
Open AccessAnalysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression
Therapeutic strategies attacking oral squamous cell carcinoma have not essentially succeeded to improve long-term prognosis and overall survival over the last decades. Therefore, in this study, we aimed to ill...
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Article
Open AccessHuman oral cells’ response to different endodontic restorative materials: an in vitro study
The aim of this study was to compare the biological interaction of human osteoblasts and cells of the human periodontal ligament (PDL) with different endodontic restorative material as Mineral Trioxide Aggrega...
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Open AccessSurgery first - prediction of surgical movements based on untreated cases
