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Article
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse
Here it is shown that T-cell receptors accumulate at the immunological synapse after stimulation with cognate antigen and are released in extracellular microvesicles by an ESCRT-dependent mechanism, the microv...
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Article
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop
Self-reactive CD4 T cells are thought to have a central role in the pathogenesis of many chronic inflammatory human diseases. Microbial peptides can activate self-reactive T cells, but the structural basis for...
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Chapter and Conference Paper
The Guanidinium Group: A Key Player in Molecular Recognition