5 Result(s)
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Susana Boluda
Neurology
Neurosciences
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Article
Open AccessPathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in th...
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Article
Open AccessTransmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhage...
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Article
Open AccessInduction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains
In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as af...
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Article
Alzheimer’s senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures
Extracellular accumulation of Aβ peptides and intracellular aggregation of hyperphosphorylated tau proteins are the two hallmark lesions of Alzheimer disease (AD). The senile plaque is made of a core of extrac...
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Article
Meningeal melanocytosis: a possibly useful treatment for a rare primary brain neoplasm
