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Article
Reply to: Questioning the cycad theory of Kii ALS–PDC causation
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Article
Endemic parkinsonism: clusters, biology and clinical features
The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or...
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Article
Open AccessPathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in th...
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Chapter and Conference Paper
Visual Deep Learning-Based Explanation for Neuritic Plaques Segmentation in Alzheimer’s Disease Using Weakly Annotated Whole Slide Histopathological Images
Quantifying the distribution and morphology of tau protein structures in brain tissues is key to diagnosing Alzheimer’s Disease (AD) and its subtypes. Recently, deep learning (DL) models such as UNet have been...
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Article
Open AccessTransmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhage...
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Article
Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers
Microduplications of the 17q21.31 chromosomal region encompassing the MAPT gene, which encodes the Tau protein, were identified in patients with a progressive disorder initially characterized by severe memory imp...
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Article
Open AccessInduction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains
In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as af...
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Article
Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix
In Alzheimer’s disease (AD), Tau and Aβ aggregates involve sequentially connected regions, sometimes distantly separated. These alterations were studied in the pillar of the fornix (PoF), an axonal tract, to a...
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Article
Increased prevalence of granulovacuolar degeneration in C9orf72 mutation
Granulovacuolar degeneration (GVD) is usually found in Alzheimer’s disease (AD) cases or in elderly individuals. Its severity correlates positively with the density of neurofibrillary tangles (NFTs). Mechanism...
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Article
Alzheimer’s senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures
Extracellular accumulation of Aβ peptides and intracellular aggregation of hyperphosphorylated tau proteins are the two hallmark lesions of Alzheimer disease (AD). The senile plaque is made of a core of extrac...
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Article
Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology
We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with ...
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Article
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains
Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographicall...
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Article
A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis
Current neuropathological Alzheimer’s disease (AD) criteria from the National Institute on Aging-Alzheimer’s Association (NIA-AA) incorporate two staging systems for Aβ pathology, namely the Thal Aβ phase (TA...
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Article
Meningeal melanocytosis: a possibly useful treatment for a rare primary brain neoplasm
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Article
Refractory nonconvulsive status epilepticus in Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease (CJD) is a rare human transmissible spongiform subacute encephalopathy. The most common clinical manifestations of CJD include rapidly progressive dementia, behavioural changes, cereb...
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Article
Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies
Brain banks are facilities providing an interface between generous donation of nervous tissues and research laboratories devoted to increase our understanding of the diseases of the nervous system, discover ne...
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Article
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer’s disease
Recent studies have shown the co-existence of α-synuclein and phosphorylated tau (pTau) in several neurodegenerative diseases. Here, we report two autopsy cases of combined multiple system atrophy (MSA) and Al...
