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Article
Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers
Microduplications of the 17q21.31 chromosomal region encompassing the MAPT gene, which encodes the Tau protein, were identified in patients with a progressive disorder initially characterized by severe memory imp...
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Article
Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix
In Alzheimer’s disease (AD), Tau and Aβ aggregates involve sequentially connected regions, sometimes distantly separated. These alterations were studied in the pillar of the fornix (PoF), an axonal tract, to a...
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Article
Increased prevalence of granulovacuolar degeneration in C9orf72 mutation
Granulovacuolar degeneration (GVD) is usually found in Alzheimer’s disease (AD) cases or in elderly individuals. Its severity correlates positively with the density of neurofibrillary tangles (NFTs). Mechanism...
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Article
Alzheimer’s senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures
Extracellular accumulation of Aβ peptides and intracellular aggregation of hyperphosphorylated tau proteins are the two hallmark lesions of Alzheimer disease (AD). The senile plaque is made of a core of extrac...
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Article
Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology
We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with ...
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Article
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains
Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographicall...
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Article
A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis
Current neuropathological Alzheimer’s disease (AD) criteria from the National Institute on Aging-Alzheimer’s Association (NIA-AA) incorporate two staging systems for Aβ pathology, namely the Thal Aβ phase (TA...
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Article
Meningeal melanocytosis: a possibly useful treatment for a rare primary brain neoplasm
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Article
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer’s disease
Recent studies have shown the co-existence of α-synuclein and phosphorylated tau (pTau) in several neurodegenerative diseases. Here, we report two autopsy cases of combined multiple system atrophy (MSA) and Al...