-
Article
Circulating prolactin concentrations and risk of type 2 diabetes in US women
Prolactin, a multifunctional hormone, is involved in regulating insulin sensitivity and glucose homeostasis in experimental studies. However, whether circulating concentrations of prolactin are associated with...
-
Article
Circulating Hormones and Mammographic Density in Premenopausal Women
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic...
-
Article
Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women
In a cross-sectional analysis, we evaluated the associations of usual total alcohol and wine intake with a comprehensive profile of mid-luteal phase urinary estrogens and estrogen metabolites (referred to join...
-
Article
Alcohol Consumption and Risk of Breast Cancer by Tumor Receptor Expression
In epidemiologic studies, alcohol consumption appears more strongly associated with risk of estrogen receptor (ER)-positive than ER-negative breast cancer. However, this association has not been assessed by ot...
-
Article
Open AccessThe association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers
Adult body mass index (BMI) has been associated with urinary melatonin levels in humans; however, whether earlier-life body size is associated with melatonin, particularly among night shift workers, remains un...
-
Article
Open AccessShort-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women
Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change i...
-
Article
The Relationship Between Bilateral Oophorectomy and Plasma Hormone Levels in Postmenopausal Women
Oophorectomy prior to natural menopause reduces breast cancer risk. We evaluated whether timing of oophorectomy (during premenopause vs. postmenopause) or hysterectomy was associated with hormone levels, speci...
-
Article
The Association of Reproductive and Lifestyle Factors with a Score of Multiple Endogenous Hormones
We recently reported that high levels of multiple sex and growth hormones were associated with increased postmenopausal breast cancer risk. Limited research has explored the relationship between reproductive, ...
-
Article
Open AccessPlasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study
Moderate to severe premenstrual syndrome (PMS) affects 8–20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk. However, vitamin D status is influenced ...
-
Article
Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women
Analgesic use has been hypothesized to reduce the risk of some cancers, with inverse associations between analgesics and colon cancer, and suggestive inverse associations for breast cancer. Estrogen metabolite...
-
Article
Updates from the Editors
-
Article
Body Size in Relation to Urinary Estrogens and Estrogen Metabolites (EM) Among Premenopausal Women during the Luteal Phase
Estrogen metabolism profiles may play an important role in the relationship between body size and breast carcinogenesis. Previously, we observed inverse associations between current body mass index (BMI) and p...
-
Article
Open AccessGenetic variability in IGF-1 and IGFBP-3 and body size in early life
Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previ...
-
Article
Dietary Fat, Fiber, and Carbohydrate Intake and Endogenous Hormone Levels in Premenopausal Women
The authors conducted a cross-sectional study to investigate the associations of fat, fiber, and carbohydrate intake with endogenous estrogen, androgen, and insulin-like growth factor (IGF) levels among 595 pr...
-
Article
Circulating Sex Steroids and Breast Cancer Risk in Premenopausal Women
Evidence from both laboratory and epidemiologic studies indicate a key role of hormones in the etiology of breast cancer. In epidemiologic studies, indirect data, including the consistent associations observed...
-
Article
Open AccessA prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
Rheumatoid arthritis (RA) is more common in females than males and sex steroid hormones may in part explain this difference. We conducted a case–control study nested within two prospective studies to determine...
-
Article
Open AccessBiological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome
Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations c...