![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessInfluence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials
Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recogni...
-
Article
Open AccessMeasuring the impact of zero-cases studies in evidence synthesis practice using the harms index and benefits index (Hi-Bi)
In evidence synthesis practice, dealing with studies with no cases in both arms has been a tough problem, for which there is no consensus in the research community. In this study, we propose a method to measur...
-
Chapter
Complementary Therapies for Renal Diseases
Complementary therapies are commonly used to prevent and treat various medical conditions worldwide. The chapter begins with a description of the epidemiology of complementary therapies use among individuals w...
-
Reference Work Entry In depth
N-of-1 Randomized Trials
Single-subject trials have a rich history in the behavioral sciences, but a much more limited history in clinical medicine. This chapter deals with a particular single-subject design, the N-of-1 randomized con...
-
Chapter
Development of a Natural Health Product Active Surveillance Method in Outpatient Centers in Canada
Natural health products (NHPs) are commonly used across the globe. Pre-market regulations for NHPs vary considerably by jurisdiction and little is known about clinically relevant interactions with other produc...
-
Article
Study of Natural Products Adverse Reactions (SONAR) in Adults with Mental Health Conditions: A Cross-Sectional Study
Mental illness is a leading cause of non-fatal disease burden worldwide. Natural health products (NHPs) are sought by patients with mental health conditions as a safer and more ‘natural’ option than convention...
-
Article
Open AccessUtilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-...
-
Article
Open AccessMusic Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial
To demonstrate feasibility of a music medicine intervention trial in pediatric intensive care and to obtain information on sedation and analgesia dose variation to plan a larger trial.
-
Living Reference Work Entry In depth
N-of-1 Randomized Trials
Single-subject trials have a rich history in the behavioral sciences, but a much more limited history in clinical medicine. This chapter deals with a particular single-subject design, the N-of-1 randomized con...
-
Article
From Boulder to Stockholm in 70 Years: Single Case Experimental Designs in Clinical Research
With the objective of increasing the magnitude of treatment effects in behavioral health, there is steadily growing interest in tailoring assessments and interventions to better match individual needs. This al...
-
Article
Evaluation of a Web-Based, ‘Purchase Event’ Intensive Monitoring Method for Pharmacovigilance of Natural Health Products: Lessons and Insights from Development Work in New Zealand
Intensive monitoring methods are used in pharmacovigilance for prescription medicines but have not yet been implemented for natural health products (NHPs).
-
Article
Open AccessExperiences of shared decision-making in community rehabilitation: a focused ethnography
Shared decision-making (SDM) can advance patient satisfaction, understanding, goal fulfilment, and patient-reported outcomes. We lack clarity on whether this physician-focused literature applies to community r...
-
Article
Differences in attentional control and white matter microstructure in adolescents with attentional, affective, and behavioral disorders
Adolescence is a critical time of physiological, cognitive, and social development. It is also a time of increased risk-taking and vulnerability for psychopathology. White matter (WM) changes during adolescenc...
-
Article
Open AccessMusic Use for Sedation in Critically ill Children (MUSiCC trial): study protocol for a pilot randomized controlled trial
Stress induced by pain and anxiety is common in pediatric intensive care unit (PICU) patients. Sedation/analgesia in PICU is usually achieved through various analgesics and sedatives. Excessive use of these dr...
-
Article
Individualized health-related quality of life instrument Measure Yourself Medical Outcome Profile (MYMOP) and its adaptations: a critical appraisal
Health-related quality of life (HRQL) is increasingly recognized for its importance in health research. As there is increasing recognition of the inter-individual difference in response to therapeutic interven...
-
Article
Open AccessImproving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT)
Inadequate and poor quality outcome reporting in clinical trials is a well-documented problem that impedes the ability of researchers to evaluate, replicate, synthesize, and build upon study findings and impac...
-
Article
Open AccessTurning a blind eye and a deaf ear to traditional and complementary medicine practice does not make it go away: a qualitative study exploring perceptions and attitudes of stakeholders towards the integration of traditional and complementary medicine into medical school curriculum in Uganda
A substantial proportion of healthcare professionals have inadequate understanding of traditional and complementary medicine and often consider their use inappropriate.
-
Article
Open AccessActive versus passive adverse event reporting after pediatric chiropractic manual therapy: study protocol for a cluster randomized controlled trial
Patient safety performance can be assessed with several systems, including passive and active surveillance. Passive surveillance systems provide opportunity for health care personnel to confidentially and volu...
-
Article
Open AccessPediatric training and practice of Canadian chiropractic and naturopathic doctors: a 2004–2014 comparative study
To assess chiropractic (DC) and naturopathic doctors’ (ND) knowledge, attitudes, and behaviour with respect to the pediatric patients in their practice.
-
Article
Open AccessProtocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines
N-of-1 trials are multiple cross-over trials done in individual participants, generating individual treatment effect information. While reporting guidelines for the CONSORT Extension for N-of-1 trials (CENT) a...