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Open AccessEffects of cadmium on glucose transport in rat adipocytes and human erythrocytes: stimulation of GLUT1 catalytic activity
The effects of cadmium on facilitative glucose transporter function In rat adipocytes were studied. A short (30 min) incubation with cadmium resulted in stimulation of 3-O-methyl-D-glucose (3OMG ) equilibrium ...
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Open AccessRapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, α and β, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-α is highly expressed in lipogenic tissues whereas...
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Article
Open AccessHeterogeneous HBV mutants coexist in Korean hepatitis B patients
Although many hepatitis B virus (HBV) mutants have been found in all open reading frames since the precore defective mutant was initially reported, systematic investigations of diverse HBV mutant populations i...
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Open AccessThe regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor recepto...
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Prevalence of congenital malformations and genetic diseases in Korea
A nationwide investigation of congenital malformations and genetic diseases in Korea was conducted by analyzing Medical Insurance data for infants aged under 1 year. Medical Insurance data were obtained for 1...
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Open AccessOverexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells
Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expressed in neuronal precursors in the develo** nervous system. The function of Ngn1 in neurogenesis has been shown in various aspe...
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Pott's paraplegia in patients with severely deformed dorsal or dorsolumbar spines: treatment and prognosis
Study design: Pott's paraplegic patients with severe spinal deformity were reviewed retrospectively after being treated with chemotherapy and/or decompressive surgery.
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Open AccessForskolin promotes astroglial differentiation of human central neurocytoma cells
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation of neurocytoma cel...
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The molecular basis of phenylketonuria in Koreans
Phenylketonuria (PKU) is an inborn error of metabolism that results from a deficiency of phenylalanine hydroxylase (PAH). We characterized the PAH mutations of 79 independent Korean patients with PKU or hyperphen...
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Correction: Corrigendum: Small molecule–based reversible reprogramming of cellular lifespan
Nature Chemical Biology 2, 369–374 (2006); published online 11 June 2006; corrected after print 22 December 2006 In the version of this article initially published, no competing financial interests were declar...
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Open AccessResveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive propertie...
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Article
Open AccessCyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kin...
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Retraction Note: Small molecule–based reversible reprogramming of cellular lifespan
In this paper, we described the application of magnetism-based interaction capture (MAGIC) to find a small-molecule protein target. MAGIC identified the protein ATM as the target of CGK733, a small molecule re...
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Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cell in established rat liver fibrosis model
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Open AccessMesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Mesenchymal stem cells (MSCs) secrete bioactive factors that exert diverse responses in vivo. In the present study, we explored mechanism how MSCs may lead to higher functional recovery in the animal stroke model...
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Open AccessThe function of p27KIP1 during tumor development
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitor...
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MALDI-TOF-MS analysis of small molecules using modified mesoporous material SBA-15 as assisted matrix
Mesoporous silica, SBA-15 was successfully functionalized with quinoline moiety, and was applied as a matrix in the MALDI-TOF-MS analysis of small molecules. The modified SBA-15 material [SBA-15-8-(3-(triethox...
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Spinal deformity
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Open AccessMacronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food products has...
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Open AccessCurrent implications of cyclophilins in human cancers
