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Article
Open AccessA bench study on the prevention of lung-to-lung aspiration with double-lumen endobronchial tubes and bronchial blockers
Effective lung isolation prevents lung-to-lung aspiration during thoracotomy for the management of hemoptysis. Double-lumen endobronchial tubes (DLT) and bronchial blockers are commonly used for lung separatio...
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Article
Open AccessTongue retraction using a McIvor blade improves airway condition during fiberoptic intubation: a randomized controlled trial
Airway clearance is crucial for successful fiberoptic intubation. We hypothesized that tongue retraction using a McIvor blade could facilitate fiberoptic intubation. This randomized clinical trial aimed to com...
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Article
Mutation spectrum and genotype–phenotype correlations in 157 Korean CADASIL patients: a multicenter study
CADASIL is an inherited disease caused by mutations in the NOTCH3 gene. We aimed to investigate the mutation and clinical spectrum, and genotype–phenotype correlations of Korean CADASIL patients. Samples from 492...
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Article
Effect of isomaltulose used for osmotic extraction of Prunus mume fruit juice substituting sucrose
This study evaluated the applicability of isomaltulose as a sucrose substitute in the osmotic extraction of Prunus mume fruit juice. Isomaltulose (20 mM) significantly reduced the uptake of a fluorescent tracer—2...
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Article
Open AccessAbsorption rate of krill oil and fish oil in blood and brain of rats
Krill (Euphausia superba) is a small marine crustacean with a lipid content. The mechanism of Krill oil function is not clear yet and research reports on the absorption rate of the phospholipids of krill oil in t...
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Article
Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats
The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced const...
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Article
Open AccessThe attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats
Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord isch...
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Article
Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells
Data from animal experiments suggest that exposure to general anesthetics in early life inhibits neurogenesis and causes long-term memory deficit. Considering short operating times and the popularity of sevofl...
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Article
Open AccessSimvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions
Ischemia and the following reperfusion damage are critical mechanisms of spinal cord injury. Statins have been reported to decrease ischemia–reperfusion injury in many organs including the spinal cord. Anti-ox...
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Article
Isoflurane decreases proliferation and differentiation, but none of the effects persist in human embryonic stem cell-derived neural progenitor cells
Volatile anesthetics are a potential risk for cognitive impairment in the develo** brain. Isoflurane causes cell death, reduces neurogenesis, and changes neuronal differentiation. In this study, the effects ...
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Article
Open AccessCactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats
Korean cactus Cheonnyuncho (Opuntia humifusa) is rich in pectin, phenols, flavonoids, and minerals such as calcium and phosphorus. Some Koreans drink Cheonnyuncho juice prepared by grinding Cheonnyuncho with wate...
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Article
Open AccessAn adaptive detection method for fetal chromosomal aneuploidy using cell-free DNA from 447 Korean women
Noninvasive prenatal testing (NIPT) using massively parallel sequencing of cell-free DNA (cfDNA) is increasingly being used to predict fetal chromosomal abnormalities. However, concerns over erroneous predicti...
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Article
Topical application of spent coffee ground extracts protects skin from ultraviolet B-induced photoaging in hairless mice
The aim of this study was to evaluate the protective effect of spent coffee ground (SCG) on ultraviolet (UV) B-induced photoaging in hairless mice. The oil fraction (OSCG) and ethanol extract (ESCG) of SCG wer...
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Article
Open AccessComparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy
Noninvasive prenatal testing (NIPT) to detect fetal aneuploidy using next-generation sequencing on ion semiconductor platforms has become common. There are several sequencers that can generate sufficient DNA r...
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Article
Comparison of the size 3 and size 4 ProSeal™ laryngeal mask airway in anesthetized, non-paralyzed women: a randomized controlled trial
Based on experimental results, various authors have advocated a size 4 ProSeal™ laryngeal mask airway (PLMA) in preference to a size 3 PLMA for women given a neuromuscular blocking agent because the larger siz...
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Article
Anti-diabetic effects of red rose flowers in streptozotocin-induced diabetic mice
Diabetes mellitus is a common chronic metabolic disease that is of increasing concern, because it frequently leads to complications such as cardiovascular diseases and cancer. Plants have been studied as a pot...
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Article
Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer
This investigation is aimed at evaluating the epidemiologic characteristics of BRCA1/2 germline mutations in Korean patients with breast and ovarian cancer (BOC). We analyzed the entire mutational data of BRCA1/2
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Article
Mutation analysis of the APC gene in unrelated Korean patients with FAP: four novel mutations with unusual phenotype
Germline mutations within the adenomatous polyposis coli (APC) gene are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. T...
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Article
Physicochemical and bread-making properties of air flow pulverized wheat and corn flours
The air flow pulverized grain flours were prepared from American wheat (AWF), Korean wheat (KWF), and corn (CRF) at 3 different grinding speeds, 9,000, 10,000, and 11,000 rpm. The effects of grinding speed on ...
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Article
Influence of modification method and starch concentration on the stability and physical properties of modified potato starch as wall materials
The object of this study was to investigate the stability of flavor encapsulated in modified starches, and the potentiality of modified starch as wall material. For the flavor encapsulation using freeze-drying...
