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Article
Sustained Release of Doxorubicin through Semi-Interpenetrating Polymer Network-Stabilized Micelles
Develo** effective drug delivery systems plays an important role in improving the therapeutic outcomes of anticancer agents. In this study, we investigated the potential of a micellar delivery system modifie...
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Article
Open AccessApoptotic effect of physcion isolated from marine fungus Microsporum sp. in PC3 human prostate cancer cells
Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to...
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Article
Open AccessNetwork approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation
Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signalling pathways. Activation of c-Src from its inactive to the active state involves large-scale conformational changes, and is ...
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Article
Induction of Nrf2-mediated phase II detoxifying/antioxidant enzymes in vitro by chitosan-caffeic acid against hydrogen peroxide-induced hepatotoxicity through JNK/ERK pathway
Chemical modification of chitosan is a promising method for the improvement of biological activity. In this study, chitosan-caffeic acid (CCA) was prepared and its in vitro hepatoprotective ability against hyd...
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Article
Open AccessA Spirulina maxima-derived peptide inhibits HIV-1 infection in a human T cell line MT4
Human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS). Anti-HIV agents targeting various steps in HIV life cycle have been developed; however, so far, no effec...
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Article
Open AccessGliotoxin from the marine fungus Aspergillus fumigatus induces apoptosis in HT1080 fibrosarcoma cells by downregulating NF-κB
Gliotoxin has been recognized as an immunosuppressive agent for a long time. Recently, it was reported to have antitumor properties. However, the mechanisms by which it inhibits tumors remain unclear. Here, we...
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Article
Gallic Acid-g-Chitosan Modulates Inflammatory Responses in LPS-Stimulated RAW264.7 Cells Via NF-κB, AP-1, and MAPK Pathways
Chitosan is a naturally occurring polysaccharide, which has exhibited antioxidant, antimicrobial, and anti-cancer activities among others. Modification of chitosan by grafting phenolic compounds is a good stra...
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Article
Antihypertensive peptide purified from Styela clava flesh tissue stimulates glucose uptake through AMP-activated protein kinase (AMPK) activation in skeletal muscle cells
Previously, our group described an antihypertensive peptide (Ala-His-Ile-Ile-Ile, MW: 565.3 Da) with angiotensin I-converting enzyme inhibitory and vasodilatory effects that was purified from Styela clava flesh t...
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Protocol
Derivation of Neural Precursor Cells from Human Embryonic Stem Cells for DNA Methylomic Analysis
Embryonic stem cells are self-renewing pluripotent cells with competency to differentiate into all three-germ lineages. Many studies have demonstrated the importance of genetic and epigenetic molecular mechani...
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Article
Protective effect of carvacrol from Thymus quinquecostatus Celak against tert-butyl hydroperoxide-induced oxidative damage in Chang cells
Carvacrol is a monoterpenic phenol present in Thymus quinquecostatus Celak. The protective effects of carvacrol against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage were investigated in human Chang c...
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Article
Effects of blue mussel (ME) water extracts on pentobarbital-induced sleep and the sleep architecture in mice
Blue mussel (Mytilus edulis) is a popular shellfish that is used widely in the daily diet. It has antioxidant, antimicrobial, and anticoagulant properties. The hypnotic effects of blue mussel (ME) water extracts ...
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Article
Bioactive Compounds Extracted from Ecklonia cava by Using Enzymatic Hydrolysis Protects High Glucose-Induced Damage in INS-1 Pancreatic β-Cells
Pancreatic β-cells are very sensitive to oxidative stress and this might play an important role in β-cell death in diabetes. In the present study, we investigated whether the brown alga Ecklonia cava has protecti...
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Article
Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells
Reactive oxygen species (ROS) generation is linked to dynamic actin cytoskeleton reorganization, which is involved in tumor cell motility and metastasis. Thus, inhibition of ROS generation and actin polymeriza...
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Article
Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling
We have previously isolated dieckol, a nutrient polyphenol compound, from the brown alga, Ecklonia cava (Lee et al., 2010a). Dieckol shows both antitumor and antioxidant activity and thus is of special interest f...
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Article
Neural Wiskott-Aldrich syndrome protein is required for accurate chromosome congression and segregation
The accurate distribution and segregation of replicated chromosomes through mitosis is crucial for cellular viability and development of organisms. Kinetochores are responsible for the proper congression and s...
