5 Result(s)
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Suhail Ahmed Kabeer Rasheed
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Article
Open AccessGNA13 suppresses proliferation of ER+ breast cancer cells via ERα dependent upregulation of the MYC oncogene
GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to be essential for embryonic development and vasculogen...
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Article
Open AccessThe emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors
G12 proteins comprise a subfamily of G-alpha subunits of heterotrimeric GTP-binding proteins (G proteins) that link specific cell surface G protein-coupled receptors (GPCRs) to downstream signaling molecules a...
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Article
Open AccessThymidylate synthase maintains the de-differentiated state of triple negative breast cancers
Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a r...
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Article
Open AccessGNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers
Treatment failure in solid tumors occurs due to the survival of specific subpopulations of cells that possess tumor-initiating (TIC) phenotypes. Studies have implicated G protein-coupled-receptors (GPCRs) in c...
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Open AccessMicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells
Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). Our recent study showed that control of GNA13 expression by specific mi...
