13 Result(s)
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Subhayan Chattopadhyay
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Open AccessAntihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental v...
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Weaponized genomics: potential threats to international and human security
Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussions on the risks of DNA technology being weaponized in international conflict. With tod...
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Modelling evolution at the boundaries of solid tumours
A mathematical model of eco-evolutionary dynamics estimates different birth rates of cells at the periphery of a tumour versus its centre, giving insight into locally stable evolutionary mechanisms that arise ...
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Open AccessGenome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6
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Open AccessTypes of second primary cancer influence overall survival in cutaneous melanoma
Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and ...
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Open AccessDEVOLUTION—A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genoty** data
Phylogenetic reconstruction of cancer cell populations remains challenging. There is a particular lack of tools that deconvolve clones based on copy number aberration analyses of multiple tumor biopsies separa...
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Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance
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Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma
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Open AccessTypes of second primary cancers influence survival in chronic lymphocytic and hairy cell leukemia patients
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Open AccessGenome-wide interaction and pathway-based identification of key regulators in multiple myeloma
Inherited genetic susceptibility to multiple myeloma has been investigated in a number of studies. Although 23 individual risk loci have been identified, much of the genetic heritability remains unknown. Here ...
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Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer
Survival rates are increasing in patients with prostate cancer, and second primary cancers (SPCs) are becoming more common in these patients. However, the etiology and clinical consequences of SPCs are not wel...
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Open AccessMultiple myeloma: family history and mortality in second primary cancers
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Open AccessEnrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study
Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myel...
