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  1. Article

    Open Access

    Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals

    Vision plays a crucial role in instructing the brain’s spatial navigation systems. However, little is known about how vision loss affects the neuronal encoding of spatial information. Here, recording from head...

    Kadjita Asumbisa, Adrien Peyrache, Stuart Trenholm in Nature Communications (2022)

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  2. No Access

    Article

    Magnetically guided virus stam** for the targeted infection of single cells or groups of cells

    To understand and control complex tissues, the ability to genetically manipulate single cells is required. However, current delivery methods for the genetic engineering of single cells, including viral transdu...

    Rajib Schubert, Sophie Herzog, Stuart Trenholm, Botond Roska… in Nature Protocols (2019)

  3. No Access

    Article

    Virus stam** for targeted single-cell infection in vitro and in vivo

    Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers.

    Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche… in Nature Biotechnology (2018)

  4. No Access

    Article

    Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

    The authors monitored neuronal activity in mouse visual cortex during visual-motion stimulation and perturbed retinal direction selectivity. After perturbation, the proportion of posterior-motion-preferring co...

    Daniel Hillier, Michele Fiscella, Antonia Drinnenberg… in Nature Neuroscience (2017)

  5. No Access

    Article

    Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations

    Fine-scale synchrony of neural activity determines the nature of neural coding, but its underlying mechanisms are unclear. Here the authors find that coincident electrical and chemical synaptic inputs are nonl...

    Stuart Trenholm, Amanda J McLaughlin, David J Schwab… in Nature Neuroscience (2014)

  6. No Access

    Article

    Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition

    In vertebrate vision, the two types of photoreceptors, rods and cones, operate under low and bright light intensities, respectively. Here the authors show that under bright light conditions, when rods are not ...

    Tamas Szikra, Stuart Trenholm, Antonia Drinnenberg… in Nature Neuroscience (2014)

  7. No Access

    Article

    Lag normalization in an electrically coupled neural network

    In this study, the authors show that velocity-dependent lag normalization in the retina is accomplished via a subset of adjacent directionally selective ganglion cells that are electrically coupled, allowing e...

    Stuart Trenholm, David J Schwab, Vijay Balasubramanian… in Nature Neuroscience (2013)