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Article
Open AccessCRISPR-clear imaging of melanin-rich B16-derived solid tumors
Tissue clearing combined with deep imaging has emerged as a powerful technology to expand classical histological techniques. Current techniques have been optimized for imaging sparsely pigmented organs such as...
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Protocol
Magnetically Single-Cell Virus Stam**
Single-cell engineering via virus based genetic manipulation allows the possibility of understanding of complex tissues. However, current delivery methods for the genetic engineering of single cells via viral ...
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Article
Magnetically guided virus stam** for the targeted infection of single cells or groups of cells
To understand and control complex tissues, the ability to genetically manipulate single cells is required. However, current delivery methods for the genetic engineering of single cells, including viral transdu...
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Article
Virus stam** for targeted single-cell infection in vitro and in vivo
Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers.
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Article
Nanomechanical map** of first binding steps of a virus to animal cells
Viral infection is initiated when a virus binds to cell surface receptors. Because the cell membrane is dynamic and heterogeneous, imaging living cells and simultaneously quantifying the first viral binding ev...
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Article
Open AccessThe biomechanical properties of an epithelial tissue determine the location of its vasculature
An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that ...
