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Article
Open AccessRNA alternative splicing impacts the risk for alcohol use disorder
Alcohol use disorder (AUD) is a complex genetic disorder characterized by problems arising from excessive alcohol consumption. Identifying functional genetic variations that contribute to risk for AUD is a maj...
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Article
Open AccessIntegration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
Genome-wide association studies (GWAS) have identified more than 40 loci associated with Alzheimer’s disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown, imped...
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Article
Open AccessNeural mechanisms underlying the effects of physical fatigue on effort-based choice
Physical fatigue crucially influences our decisions to partake in effortful action. However, there is a limited understanding of how fatigue impacts effort-based decision-making at the level of brain and behav...
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Article
Open AccessHighly robust model of transcription regulator activity predicts breast cancer overall survival
While several multigene signatures are available for predicting breast cancer prognosis, particularly in early stage disease, effective molecular indicators are needed, especially for triple-negative carcinoma...
