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Article
The Chromatographic Role in High Resolution Mass Spectrometry for Non-Targeted Analysis
Resolution improvements in time-of-flight instrumentation and the emergence of the Orbitrap mass spectrometer have researchers using high resolution mass spectrometry to determine elemental compositions and pe...
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Article
Open AccessHigh resolution clustering of Salmonella enterica serovar Montevideo strains using a next-generation sequencing approach
Next-Generation Sequencing (NGS) is increasingly being used as a molecular epidemiologic tool for discerning ancestry and traceback of the most complicated, difficult to resolve bacterial pathogens. Making a l...
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Article
Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats
17-(Allylamino)-17-demethoxygeldanamycin (17AAG), an analogue of the benzoquinone ansamycin geldanamycin, has been extensively studied preclinically and is being evaluated clinically. Studies were performed to...
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Article
Experimental factors affecting the quality and reproducibility of MALDI TOF mass spectra obtained from whole bacteria cells
Numerous experimental factors are shown to significantly influence the spectra obtained when bacteria are analyzed by MALDI TOF/MS. Detailed investigation of the instrument parameters and sample preparation ar...
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Chapter
Electrospray Mass Spectrometry for Fumonisin Detection and Method Validation
Fumonisins are a structurally related group of mycotoxins, characterized by a 19-20 carbon aminopolyhydroxy-alkyl chain which is diesterified with propane-1,2,3tricarboxylic acid (tricarballylic acid). These m...
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Article
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats
Purpose: 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) is an analogue of the benzoquinone ansamycin compound 17-(allylamino)-17-demethoxygeldanamycin (17AAG), which is currently being evaluated i...
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Article
Mass spectrometry and good laboratory practices
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Chapter
Quantitation and Identification of Fumonisins by Liquid Chromatography/Mass Spectrometry
A method was evaluated for the quantitation and identification of fumonisins by on-line liquid chromatography/mass spectrometry (LC/MS) with electrospray ionization. A linear response in the full-scan mode wit...
