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Open AccessMonte Carlo based dosimetry of extraoral photobiomodulation for prevention of oral mucositis
Photobiomodulation therapy (PBMT) is recommended for prevention and treatment of oral mucositis, a painful condition that occurs in cancer patients. Intraoral PBMT is limited to treating distal oral mucosa and...
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Article
Application of big data analyses to compare the impact of oral and gastrointestinal mucositis on risks and outcomes of febrile neutropenia and septicemia among patients hospitalized for the treatment of leukemia or multiple myeloma
Oral ulcerative mucositis (UM) and gastrointestinal mucositis (GIM) have been associated with increased likelihood of systemic infection (bacteremia and sepsis) in patients being treated for hematological mali...
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Article
A common infrastructure for real-world patient-reported symptoms: one size fits many
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Chapter
Introduction to Modern Cancer Diagnosis and Survivorship
This chapter gives the reader an overview of cancer diagnosis and what it means to be a cancer survivor. It also briefly explains the future and challenges in supportive care in cancer in the era of precision ...
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Article
Open AccessA hypothesis for the pathogenesis of radiation-induced oral mucositis: when biological challenges exceed physiologic protective mechanisms. Implications for pharmacological prevention and treatment
Oral mucositis (OM) remains a significant unmet need for patients being treated with standard concomitant chemoradiation (CRT) regimens for head and neck cancers (HNC). OM’s pathogenesis is complex and include...
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Article
Treatment for Oral Mucositis—Current Options and an Update of Small Molecules Under Development
Despite its history as one of the most impactful toxicities associated with cytotoxic cancer therapy, oral mucositis (OM) remains an unmet clinical need which affects hundreds of thousands of patients. Descrip...
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Article
Industry and MASCC—an opportunity not to be missed
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Article
Open AccessRobust pathway sampling in phenotype prediction. Application to triple negative breast cancer
Phenotype prediction problems are usually considered ill-posed, as the amount of samples is very limited with respect to the scrutinized genetic probes. This fact complicates the sampling of the defective gene...
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Chapter and Conference Paper
Sampling Defective Pathways in Phenotype Prediction Problems via the Holdout Sampler
In this paper, we introduce the holdout sampler to find the defective pathways in high underdetermined phenotype prediction problems. This sampling algorithm is inspired by the bootstrap** procedure used in ...
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Chapter and Conference Paper
Sampling Defective Pathways in Phenotype Prediction Problems via the Fisher’s Ratio Sampler
In this paper, we introduce the Fisher’s ratio sampler that serves to unravel the defective pathways in highly underdetermined phenotype prediction problems. This sampling algorithm first selects the most disc...
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Chapter and Conference Paper
Comparison of Different Sampling Algorithms for Phenotype Prediction
In this paper, we compare different sampling algorithms used for identifying the defective pathways in highly underdetermined phenotype prediction problems. The first algorithm (Fisher’s ratio sampler) selects...
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Article
Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations
There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radi...
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Chapter and Conference Paper
Design of Biomedical Robots for the Analysis of Cancer, Neurodegenerative and Rare Diseases
Studies of genomics make use of high throughput technology to discover and characterize genes associated with cancer and other illnesses. Genomics may be of particular value in discovering mechanisms and inter...
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Article
Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy
Diarrhea is a common toxicity of chemotherapy, but the practice of reporting only severe grades (≥ 3) in clinical trials results in misleading conclusions of significance. Epidemiology remains poorly described...
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Article
Emerging evidence on the pathobiology of mucositis
Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published...
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Article
The Economic Burden of Toxicities Associated with Cancer Treatment: Review of the Literature and Analysis of Nausea and Vomiting, Diarrhoea, Oral Mucositis and Fatigue
Side effects or toxicities are frequent, undesirable companions of almost all forms of non-surgical cancer therapy. It is unusual for patients to complete treatment with radiation or chemotherapy without exper...
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Article
Emerging evidence on the pathobiology of mucositis
Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published...
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Book
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Chapter
Mucositis
Alimentary tract (AT) mucositis is a serious and debilitating side effect of cancer therapy, primarily characterised by damage to the mucous membranes throughout the AT, and associated with mouth ulcers and pa...
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Article
A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy
Misoprostol, a synthetic analog of prostaglandin E1, has anti-inflammatory and mucosa-protecting properties. The objective of this study was to evaluate the efficacy of misoprostol oral rinse in reducing the s...
