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  1. Article

    Open Access

    The Burden of Proof studies: assessing the evidence of risk

    Exposure to risks throughout life results in a wide variety of outcomes. Objectively judging the relative impact of these risks on personal and population health is fundamental to individual survival and socie...

    Peng Zheng, Ashkan Afshin, Stan Biryukov, Catherine Bisignano in Nature Medicine (2022)

  2. Article

    Open Access

    Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

    Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Mea...

    Shu-Chun Chuang, Heiner Boeing, Stein Emil Vollset, Øivind Midttun in Immunity & Ageing (2016)

  3. Article

    Open Access

    Supplemental folic acid in pregnancy and childhood cancer risk

    We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999–2010, and 799 children diagnosed later with cancer.

    Jan Helge Seglem Mortensen, Nina Øyen, Tatiana Fomina in British Journal of Cancer (2016)

  4. No Access

    Article

    Functional inference of the methylenetetrahydrofolate reductase 677 C > T and 1298A > C polymorphisms from a large-scale epidemiological study

    Two functional single nucleotide polymorphisms, 677C > T and 1298A > C have been described for the methylenetetrahydrofolate (MTHFR) gene. Both are associated with reduced enzyme activity in vitro. For the 677...

    Arve Ulvik, Per M. Ueland, Åse Fredriksen, Klaus Meyer in Human Genetics (2007)